| Abstract [eng] |
From the end of the 9th decade when the use of antiretroviral drugs was initiated in the treatment of HIV patients it lead to the enormous progress. Currently used drugs are divided into five classes according to the mechanism of action: • nucleoside/ nucleotide reverse transcriptase inhibitors (NRTIs); • non-nucleoside reverse transcriptase inhibitor (NNATI); • protease inhibitors (PI); • fusion inhibitors (FI); • integrase inhibitors (II). Even in the treatment of modern method of application of combined antiretroviral therapy (ART), a virus can not be completely destroyed. However, for HIV infection in particular, the dynamic inherent variability develops resistance to drugs. This is happening more quickly than in other treated infection cases. The operation principles of evolution, in partial inhibition, drug-resistant virus strains are selected and rapidly become dominant. Damage to a person is that following the initiated treatment the viral load increases and the disease progresses. Damage to the public is that the multiple resistance virus strains are transmitted to others, so untreated patients decreases the likelihood of treatment success. To avoid resistance, viremia suppression should be the most potent and long-term. This can be achieved only through the combination of ART, which is efficient and easy to use. For these reasons, the initial success of HIV resistance to antiretroviral drugs in a new infected patients have a significant impact on the future success of their treatment, and the overall assessment of the prevalence of resistant strains in Lithuania. |
