Title SARS-COV-2 infection in children of Lviv region /
Translation of Title SARS-COV-2 інфекція у дітей Львівщини.
Authors Lytvyn, Halyna ; Dubey, Leonid ; Stasiv, Maria ; Dybas, Iryna ; Ivanchenko, Natalia ; Dubey, Natalia ; Kalchuk, Olena ; Chkhaidze, Ivane ; Valiulis, Arūnas
DOI 10.25040/ntsh
Full Text Download
Is Part of Proceedings of the Shevchenko Scientific Society. Medical sciences.. Lviv : Danylo Halytskyi Lviv National Medical University. 2024, vol. 76, iss. 2, p. 1-12.. ISSN 2708-8634. eISSN 2708-8642
Keywords [eng] COVID-19 ; SARS-CoV-2 ; children ; cough ; pneumonia ; diarrhea ; D-dimer ; thrombocytopenia ; interleukins.
Abstract [eng] Introduction: During different epidemic periods of COVID-19, from 3.5% to 28% of pediatric patients required hospitalization [1–3], and the mortality rate was about 0.1% [4–5]. The clinical spectrum of pediatric COVID-19 is wide - from asymptomatic to critically severe disease complicated by acute respiratory distress syndrome, requiring mechanical ventilation [6]. Aim: To analyze the clinical and laboratory features of COVID-19 in children of different ages. Patients and methods: A prospective study was conducted with the participation of 110 patients aged one to 18 years who were treated with a diagnosis of COVID-19 at the «Okhmatdyt» Hospital in Lviv in 2021-2022. The diagnosis was verified by a positive PCR test for SARS-CoV-2 from a nasocytogram. Three age groups were formed: the first included 28 children aged 1 to 5 years, the second - 33 patients aged 5 to 10 years, the third - 49 patients aged 10 to 18 years. Clinical, laboratory and instrumental signs of the disease were determined in hospitalized patients. Results: Moderate COVID-19 was diagnosed in 80 patients (72.73%), severe - in 30 (27.27%), (p < 0.05). The mean/median values of inflammatory markers in patients with moderate and severe SARS-CoV-2: procalcitonin 0.05±0.03 ng/ml and 2.48±5.27 ng/ml; CRP 12.14±20.90 mg/l and 62.93±79.33 mg/l; IL-6 1.20 pg/ml and 7.50 pg/ml; IL-10 1.87±6.37 pg/ml and 22.64±60.97 pg/ml, in accordance (p < 0.05). Elevated D-dimer levels correlated with the severity of COVID-19, increasing in dynamics. The median values of the D-dimer level at the time of hospitalization and in dynamics in children with severe course were: 791.00 ng FEV/ml, 1206.00 ng FEV/ml; in moderate– 368.00 ng FEV/ml, 425.00 ng FEV/ml, (р ˂ 0.05). Among all patients with COVID-19, pneumonia was diagnosed in 46 children (41.82%) and in 19 children (63.33%) – with a severe course of the disease. Discussion: Scientific studies show that severe course of SARS-CoV-2 is more often observed in adolescents, the severity of the disease in different age groups also depends on its strain [3; 7–8]. The implementation of the prediction of severe infectious processes in children is possible when studying the levels of cytokines, procalcitonin, CRP, fibrinogen and troponin [9]. An increase in D-dimer was detected in severe COVID-19 [10–11]. Conclusions: The majority of hospitalized children developed a moderate course of COVID-19. Severe course – in children aged 10–18 years. The values of inflammatory markers were higher in children with severe COVID-19. Pneumonia developed in 41.82% of patients. Elevated D-dimer levels correlated with the severity of COVID-19.
Published Lviv : Danylo Halytskyi Lviv National Medical University
Type Journal article
Language English
Publication date 2024
CC license CC license description