| Title |
GCK monogeninio diabeto (GCK-MODY) atpažinimas gestaciniu diabetu sergančiosioms – diagnostiniai ir gydymo ypatumai: literatūros apžvalga / |
| Translation of Title |
Identification of GCK - Monogenic diabetes (GCK-MODY) in gestational diabetes subjects – diagnostic and treatment approach: literature review. |
| Authors |
Boguševičiūtė, Agnė |
| DOI |
10.53453/ms.2025.1.10 |
| Full Text |
|
| Is Part of |
Medicinos mokslai = Journal of medical sciences.. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras. 2025, vol. 13, iss. 1, p. 91-98.. ISSN 2345-0592 |
| Keywords [eng] |
MODY in gestational diabetes ; GCK-MODY ; GCK-MODY during pregnancy ; GCK-MODY treatment in gestational diabetes |
| Abstract [eng] |
Background. Maturity-onset diabetes of the young (MODY) is an autosomal dominant diabetes caused by a single gene mutation, leading to early-onset pancreatic beta-cell dysfunction. Its non-specific symptoms often result in misdiagnosis. Monogenic diabetes represents 1–5% of cases, with most pregnant women having a glucokinase (GCK) gene mutation. Accurate diagnosis is essential, as treatment strategies vary by diabetes type. Aim: to analyze and review scientific literature describing diagnostic possibilities, and treatment strategies for GCK MODY. Material and methods. A literature review was conducted by searching scientific publications in the PubMed database. The review included articles written in English and published within the last 10 years (2014–2024). Results. GCK-MODY diabetes typically has a mild course with a low risk of chronic complications, so pharmacological treatment is usually unnecessary. In pregnant women, treatment may be considered based on the fetus's genotype, especially if there are concerns about macrosomia, in which case insulin therapy is recommended. As GCK-MODY is not always diagnosed, improving identification and applying routine prenatal tests is important to reduce fetal complications. Conclusions. The diagnosis of GCK-MODY is complicated by non-specific symptoms. Genetic tests are performed to confirm the diagnosis, which are expensive, so special criteria are needed. Differentiating between MODY and gestational diabetes is important, as it determines different treatment and care strategies during pregnancy and after delivery. |
| Published |
Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2025 |
| CC license |
|
