| Title |
Chemokinų koncentracijos šlapime ir išvestinių bendro kraujo tyrimo rodiklių reikšmė inksto transplantato atmetimo diagnostikai ir prognozei / |
| Translation of Title |
The significance of urinary chemokines and complete blood count indicators for the diagnosis of kidney transplant rejection and prognosis. |
| Authors |
Mačionienė, Ernesta |
| DOI |
10.15388/vu.thesis.742 |
| Full Text |
|
| Pages |
176 |
| Keywords [eng] |
kidney transplantation ; chemokines ; allograft rejection ; biomarkers |
| Abstract [eng] |
This dissertation aimed to evaluate chemokines CXCL9 and CXCL10 as potential biomarkers of kidney transplant rejection, and prognosis and to investigate their relation to the indices of complete blood count indicators. The study included 117 patients after kidney transplantation who underwent allograft biopsy and were tested for urinary chemokine CXCL9 and CXCL10 levels. In patients with biopsy-proven allograft rejection, both urinary CXCL9 and CXCL10 levels were significantly higher than in normal histology or non-rejection-related graft pathology, except for polyoma BK virus infection. Increased urine concentrations of CXCL9 and CXCL10 were associated with a worse prognosis for the kidney graft and recipient. The association between particular histology lesions and chemokine levels were also evaluated. When evaluating the derived indices of the indicators of the general blood test, only the ratio of eosinophils to monocytes was significantly associated with the rejection of the kidney graft. Findings of the dissertation suggest that urinary and blood biomarkers could help to reduce the number of invasive kidney biopsies for posttransplant monitoring of kidney transplant recipients. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2025 |
