| Title |
Pancreatic 3D organoids and microfluidic systems-applicability and utilization in surgery: a literature review |
| Authors |
Petrauskas, Vidas ; Damaševičiūtė, Rytė ; Kielaitė-Gulla, Aistė |
| DOI |
10.3390/medicina61040623 |
| Full Text |
|
| Is Part of |
Medicina.. Basel : MDPI. 2025, vol. 61, iss. 4, art. no. 623, p. [1-14].. ISSN 1010-660X. eISSN 1648-9144 |
| Keywords [eng] |
pancreatic organoids ; organoid ; organ-on-a-chip ; PDAC |
| Abstract [eng] |
Background: Pancreatic organoids are a rapidly advancing field of research with new discoveries being made every day. A literature review was performed to answer the question of how relevant 3D pancreatic organoids are for surgery. Materials and Methods: We started our investigation by identifying articles in PubMed within the last 5 years using the keywords ((“pancreatic organoid”, OR “organ-on-a-chip”, OR “pancreatic chip” OR “3D culture methods”) AND pancreatic surgery). Only English articles were included in this literature review. This literature review was performed in a non-systematic way; articles were chosen without a predetermined protocol of inclusion and were based on the aim of the review. Results and Conclusions: There are many promising innovations in the field of 3D cultures. Drug sensitivity testing in particular holds great potential for surgical application. For locally advanced PDAC, EUS-FNB obtained cancer tissue can be cultured as organoids, and after 4 weeks, neoadjuvant treatment could be adjusted for each patient individually. Utilizing this approach could increase the number of R0 resections and possibly cure the disease. Furthermore, microfluidic devices, as a platform for pancreatic islet pre-transplant evaluation or cultivation of beta cells derived from HiPSC in vitro, promise broad application of islet transplantation to T1DM patients in the near future. |
| Published |
Basel : MDPI |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
