Title Thrombotic microagiopathy and kidney injury /
Translation of Title Thrombotic Microagiopathy and Kidney Injury.
Authors Schiebener, Lars Christoph
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Pages 41
Keywords [eng] Thrombotic microangiopathy, kidney, complement system, atypical hemolytic uremic syndrome, thrombotic thrombocytopenic purpura, ADAMTS13, endothelial injury, renal histopathology, complement inhibition, eculizumab, ravulizumab, pregnancy-associated TMA, transplant-associated TMA, secondary TMA, microvascular thrombosis, acute kidney injury, autoimmune diseases, genetic mutations, biomarkers, plasma exchange, cancer.
Abstract [eng] Thrombotic microangiopathy with its primery and secondary subtypes and their different pathogeneses, represents a very extensive picture of diseases. This literature review aims to provide a comprehensive picture of these diseases, as many of them can be potentially dangerous. Trombotic microangiopathy is characterized primarily by microvascular thrombosis and endothelial damage, as well as the resulting organ damage. Many organs can be affected, although the kidneys are primarily affected. With focus is on the latest findings of the last 5 years, immunological and molecular mechanisms, as well as therapeutic approaches and diagnostic methods, were investigated in order to gain a better understanding of this. One main focus is primarily on the ever-developing understanding of ADAMTS13 deficiency and complement dysregulation in the development of the diseases, but also on new diagnostic methods such as genetic testing and biomarkers. The effectiveness of targeted treatments with complement inhibitors, for example, was investigated, as were new therapeutic approaches. The results showed promising approaches that require further research. It was also shown that the prognosis and treatment depend above all on the correct diagnosis and adapted treatment.The integration of new knowledge has led to significant progress in research, but also shows the need of further research and development in some areas of thrombotic renal microangiopathies with the aim of improving diagnosis, personalizing treatment and guiding future nephrological research.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language English
Publication date 2025