| Abstract [eng] |
Preeclampsia is a pregnancy complication clinically manifested by hypertension and organ dysfunction, leading to significant maternal and neonatal morbidity and mortality. Since the only definitive treatment for preeclampsia is delivery, preventive measures are crucial, with aspirin being one of the most effective options. The aim of this literature review is to evaluate the effectiveness of aspirin in preventing preeclampsia, determine the optimal dosage, timing of administration, and duration of treatment. Analysis of scientific studies suggests that aspirin administration before the 16th week of pregnancy, continued until the 40th week, is the most effective preventive strategy. While some studies indicate that the effectiveness of aspirin is independent of the initiation time, this review identified a trend suggesting that early administration is associated with a lower risk of preeclampsia. The most effective aspirin dosage is 150 mg/day; however, lower doses (60–100 mg/day) are also effective and safe. Additionally, evidence suggests that taking aspirin before bedtime may be more beneficial than administration in the morning or during the day. Overall, aspirin reduces the incidence of preeclampsia, with statistically significant data supporting its effectiveness. Based on the available evidence, it is recommended that high-risk pregnant women take 150 mg of aspirin per day from the 11th–12th week of pregnancy until the 40th week, preferably before bedtime. Future research should focus on determining the optimal aspirin dosage for different risk groups and clarifying its preventive guidelines. |
