| Abstract [eng] |
Malignant pleural mesothelioma is a rare, yet notably aggressive malignancy of the pleural lining and is primarily linked to asbestos exposure. Despite advancements in diagnostics and treatment, managing this disease remains challenging, particularly in advanced stages. This thesis presents a retrospective clinical case analysis of a malignant pleural mesothelioma patient, which integrates a literature review and a comparison of treatment decisions against established guidelines. The patient’s clinical presentation, diagnostic process, treatment course, and disease progression are examined in detail. The literature review covers epidemiology and risk factors, pathophysiology and molecular biology, diagnostic methods and biomarkers, treatment methods and effectiveness, prognostic factors and survival analysis. Treatment decisions were evaluated against the European Society for Medical Oncology (ESMO) 2021/2022 guidelines, and the patient’s intensive care management was assessed based on the Surviving Sepsis Campaign guidelines of 2021. The case was further compared to another patient to highlight differences in disease trajectory and response to therapy. |
