Title Širdies nepakankamumas sepsio metu, diagnostikos ypatumai /
Translation of Title Cardiac dysfunction in sepsis: diagnostic challenges.
Authors Kondratavičiūtė, Gabija
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Pages 40
Abstract [eng] Cardiac dysfunction in sepsis is a reversible and complex form of myocardial dysfunction, the diagnosis of which remains challenging due to the lack of clear and universally accepted criteria, as well as the dynamically changing clinical status of the patient. The pathogenesis of septic cardiomyopathy is not yet fully understood but is strongly associated with systemic inflammatory response, micro- and macro-circulatory disturbances, and sympathetic nervous system overactivity. Clinically, this condition may manifest as left, right, or biventricular dysfunction. During sepsis, constant fluctuations in hemodynamic factors – such as variations in preload and afterload, fluid therapy, pharmacological effects, and comorbidities – make cardiac function assessment particularly difficult. Therefore, indicators like left ventricular ejection fraction should not be interpreted in isolation. For a more comprehensive evaluation of cardiac function, advanced echocardiographic techniques such as 2D, 3D, transesophageal echocardiography, and speckle-tracking tissue doppler imaging should be employed, based on the patient’s condition and available resources. Hemodynamic and biochemical parameters can also provide valuable insights, though cardiac biomarkers must be interpreted cautiously due to their limited specificity and potential confounding from other pathologies. Effective cardiac function assessment in sepsis requires dynamic monitoring. Further research is necessary to clarify the underlying mechanisms of sepsis-related heart failure, develop standardized diagnostic criteria, and implement advanced technologies in clinical practice. Aim: to review the literature on the diagnosis of heart failure in sepsis, highlighting its specific features, and to provide conclusions and recommendations. Methods: a literature search was conducted using the PubMed scientific database. Search terms included “heart failure,” “cardiac dysfunction,” “sepsis,” “septic cardiomyopathy,” “diagnostics,” and their variations. Open-access publications written in English and published up to April 2025 were selected if their abstracts or keywords clearly indicated relevance to the topic. Keywords: heart failure, cardiac dysfunction, sepsis, septic cardiomyopathy, diagnostics.
Dissertation Institution Vilniaus universitetas.
Type Master thesis
Language Lithuanian
Publication date 2025