| Abstract [eng] |
As cardiac conduction abnormalities and heart failure prevalence rise globally, optimizing resyn-chronization becomes increasingly important. In the context of cardiac resynchronization therapy (CRT), this thesis explores two physiological pacing methods- parahisian pacing (PHP, Syn: his -bundle area pacing HBAP) and left bundle branch area pacing (LBBAP). Both parahisian pacing and left bundle pacing are intended to enable a (more) physiological activation of the ventricles, with the aim of synchronized action of both heart chambers. However: The techniques aim at dif-ferent anatomical areas and different parts of the physiological conduction system, respectively. Despite different placement sites certain medical indications are eligible for the potential use of both techniques. The aim of this thesis is to evaluate and compare the benefits and disadvantages of PHP and LBBAP in cardiac resynchronization. A systematic literature review is conducted using PubMed, MedRxiv, and Cochrane databases. Studies are selected based on predefined criteria, including randomized controlled trials, observational studies, and systematic reviews. Analysis is performed in an extended narrative manner, incorporating descriptive and semi-quantitative analysis. |
