| Keywords [eng] |
Endoscopic Intragastric Balloon (IGB) Therapy, Non-endoscopic Intragastric Balloons, Obesity-Related Weight Loss Interventions, Comparative Analysis of Weight Reduction Methods, Gastrointestinal Devices for Obesity Treatment, Gastrointestinal Satiety Mechanisms, Minimally Invasive Obesity Therapies |
| Abstract [eng] |
The following thesis compares and investigates the clinical outcomes of endoscopic intragastric balloons implanted for usually six months, with non-invasive intragastric balloons such as the common Allurion balloon. The Allurion intragastric balloon has a treatment duration of usually four months. Over the whole world, the obesity rate is rising, so this study evaluates the minimally invasive treatment outcomes for patients who are not able or fit enough for bariatric surgery or don´t want to due to complications. This thesis mentioned endoscopic placed intragastric balloons like the Orbera, ReShape Duo and Spatz3, which are implanted and explanted with an endoscope in general anaesthesia. These endoscopically placed intragastric balloons usually managed to achieve a higher total body weight loss from 14 to 18%, combined with an excess weight loss of 65%. These balloons usually show higher complication and intolerance rates, such as nausea, early balloon explantation or gastric ulcers. Compared to these, non-invasive balloons such as the Allurion or Obalon Balloon can be implanted without endoscopy or general anaesthesia. Usually, the patients can swallow the balloons by themselves without bigger complications. Their total body weight loss is a bit lower, with 10 to 14%, but usually, these balloons are well tolerated by the patients and show complications and adverse reaction rates of 0.5%. In general, this thesis shows the importance of comparing different intragastric balloons of similar treatment durations to improve the clinical outcome of each patient. This thesis shows and summarises different outcomes of various intragastric balloon systems and shows that endoscopic balloons achieve a little bit higher weight loss outcome, but non-invasive balloons will offer a good option for patients who prefer safe, simplified and short-term treatment without any risk of endoscopy and general anaesthesia. Selecting the right balloon for each patient depends on the individual BMI, weight loss goal and personal preference. |
