| Abstract [eng] |
Abstract Objective and aim: sarcopenia is a geriatric syndrome affecting older adults worldwide. There are many interventions that are used to prevent or treat sarcopenia. That is why the aim of this work was to review existing treatment interventions (non-pharmacological and pharmacological) for sarcopenia. Design: literature review Methods: Searches were conducted in PubMed, Scopus, and Elsevier using database-specific search terms such as “elderly,”, “older adult”, “sarcopenia,” “intervention,” “treatment,” , “experimental”, and related keywords; manual searches of guideline websites were also performed. Using the PICOS framework, studies published in English over the past 10 years (2014–2024). Results: The literature review identified multiple effective interventions for sarcopenia, including resistance training, nutritional supplementation, and pharmacological treatments. Resistance training was shown to be the most effective non-pharmacological intervention, significantly improving muscle mass and strength. Nutritional supplementation, particularly with protein and vitamin D, also demonstrated positive effects on muscle maintenance and function. Pharmacological treatments, such as selective androgen receptor modulators (SARMs) and myostatin inhibitors, showed promise in increasing muscle mass and strength, but further research is needed to confirm long-term efficacy and safety. Conclusion: Sarcopenia represents a significant health concern for the elderly, with various interventions available to mitigate its effects. Resistance training and nutritional supplementation are highly effective non-pharmacological treatments, while pharmacological options hold potential but require more research. Early diagnosis and a comprehensive, personalized approach are crucial for improving outcomes in older adults with sarcopenia. |
