| Abstract [eng] |
This Master's thesis presents a comparative study of three synthesis methods for calcium hydroxyapatite (Ca₁₀(PO₄)₆(OH)₂; CHA): sol-gel, hydrothermal, and precipitation techniques. The aim was to evaluate how each method affects the structural and morphological properties of CHA and to investigate the antibacterial activity of its composites with eugenol. The results demonstrated that the sol-gel method produced CHA with the highest crystallinity and thermal stability. The hydrothermal method yielded well-defined crystals with moderate stability, while the precipitation method, though simple and cost-effective, resulted in less uniform particles. Subsequently, CHA-eugenol composites were synthesized using the precipitation method and characterized using various analytical techniques. The antibacterial analysis revealed that these composites exhibited enhanced antibacterial activity against the Gram-positive Staphylococcus aureus, compared to the Gram-negative Pseudomonas aeruginosa. These findings suggest that CHA-eugenol composites have promising potential in dental and biomedical applications. |
