| Title |
PARP9-PARP13-PARP14 axis tunes colorectal cancer response to radiotherapy |
| Authors |
Prokarenkaitė, Rimvilė ; Kuodytė, Karolina ; Gudoitytė, Greta ; Budginaitė, Elzbieta ; Naumovas, Daniel ; Strainienė, Eglė ; Veličkevičius, Kristijonas ; Dulskas, Audrius ; Šileika, Ernestas ; Venius, Jonas ; Tunaitis, Virginijus ; Pivoriūnas, Augustas ; Starkuvienė, Vytautė ; Stankevičius, Vaidotas ; Sužiedėlis, Kęstutis |
| DOI |
10.1186/s13046-025-03439-y |
| Full Text |
|
| Is Part of |
Journal of Experimental & Clinical Cancer Research.. London : Springer Nature publishing group. 2025, vol. 44, iss. 1, art. no. 199, p. 1-18.. eISSN 1756-9966 |
| Keywords [eng] |
3D cell culture ; interferon stimulated genes ; PARP13 ; PARP14 ; PARP9 ; radiosensitizers ; radiotherapy |
| Abstract [eng] |
Colorectal cancer (CRC) is the third most prevalent cancer worldwide. Despite substantial advancements in CRC therapy in recent years, ionizing radiation (IR) continues to be the predominant treatment for colon malignances. However, it still lacks the precision required for excellent therapeutic outcomes, ultimately resulting in tumor radioresistance. This study seeks to explore the potential of atypical PARPs including PARP9 , PARP12 , PARP13 and PARP14 as innovative radiosensitizing targets for CRC. |
| Published |
London : Springer Nature publishing group |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
