Title Changes in macular thickness after trabeculectomy with or without adjunctive 5-fluorouracil
Translation of Title Tinklainės geltonosios dėmės storio pokyčiai po trabekulektomijos be arba su 5-fluorouracilu.
Authors Kadziauskienė, Aistė ; Strelkauskaitė, Ernesta ; Mockevičiūtė, Eglė ; Ašoklis, Rimvydas Stanislovas ; Lesinskas, Eugenijus ; Schmetterer, Leopold
DOI 10.6001/actamedica.v24i2.3489
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Is Part of Acta medica Lituanica.. Vilnius : Lietuvos mokslų akademijos leidykla. 2017, Vol. 24, No. 2, p. 93-100.. ISSN 1392-0138. eISSN 2029-4174
Keywords [eng] retinal thickness ; macula ; trabeculectomy ; 5-fluoruracil ; intraocular pressure
Abstract [eng] Background. The aim of the study was to assess changes in macular thickness after trabeculectomy in respect to the use of 5-fluorouracil (5-FU) as well as to analyse possible associations between the postoperative changes in macular thickness and intraocular pressure (IOP). Materials and methods. The prospective observational study included 106 eyes (100 patients) with glaucoma who underwent trabeculectomy with or without 5-FU. Subsequently 5-FU needling was performed if failure of the filtrating bleb occurred. Macular thickness and the IOP were evaluated before, one week, and six months after the surgery. The mean and sectoral macular thickness was assessed using spectral domain optical coherence tomography. Results. The mean (±SD) IOP reduced from 27.71 (±6.88) mmHg at baseline to 18.3 (±8.1) mmHg one week (p < 0.001) and 15.1 (±7.6) mmHg six months (p < 0.001) after trabeculectomy. One week postoperatively, the mean macular thickness increased from 285.19 (±15.98) μm to 288.9 (±16.31) μm (p < 0.001); macular thickening was significant in all subfields (p < 0.001) and correlated positively with IOP reduction (rho = 0.312, p = 0.001 for central subfield). After six months, macula remained thicker only at the central and inner nasal subfields (p < 0.05). The changes in macular thickness were not affected by the use of 5-fluorouracil. Conclusions. Trabeculectomy may induce a slight macular thickening which is more pronounced in the early postoperative period. The IOP reduction plays an important role in this process and is associated with thicker postoperative macula. However, the use of adjunctive 5-FU has no influence on macular thickness after glaucoma surgery despite its potential hypotonic, inflammatory and cytotoxic effects.
Published Vilnius : Lietuvos mokslų akademijos leidykla
Type Journal article
Language English
Publication date 2017
CC license CC license description