| Title |
Databases and web-based tools for studying structures of protein-nucleic acid complexes |
| Authors |
Dapkūnas, Justas ; Venclovas, Česlovas |
| DOI |
10.1016/j.sbi.2025.103079 |
| Full Text |
|
| Is Part of |
Current opinion in structural biology.. London : Elsevier Ltd. 2025, vol. 94, art. no. 103079, p. [1-9].. ISSN 0959-440X. eISSN 1879-033X |
| Abstract [eng] |
Structural data on protein-DNA and protein-RNA interactions are indispensable in molecular biology research. In this article, we review available databases and other web-based resources devoted to 3D structures of protein-nucleic acid complexes. First, we describe the core databases that collect and disseminate experimental data. We then review derivative databases focused specifically on structural data on protein-nucleic acid interactions. Finally, we provide an overview of several useful web servers for structure prediction, analysis and comparison. Tools for investigating protein-nucleic acid complexes are relatively scarce. This is primarily because the methods that integrate structural information from both proteins and nucleic acids are in short supply. However, the emerging AI-driven techniques for structure prediction are expected to boost the development of such methods. |
| Published |
London : Elsevier Ltd |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
