Title Severity of hyperoxia as a risk factor in patients undergoing on-pump cardiac surgery
Translation of Title Hiperoksija kaip rizikos veiksnys pacientams, kuriems atliekamos širdies operacijos su dirbtine kraujo apytaka.
Authors Jakutis, Gabrielius ; Norkienė, Ieva ; Ringaitienė, Donata ; Jovaiša, Tomas
DOI 10.6001/actamedica.v24i3.3549
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Is Part of Acta medica Lituanica.. Vilnius : Lietuvos mokslų akademija. 2017, vol. 24, no. 3, p. 153-158.. ISSN 1392-0138. eISSN 2029-4174
Keywords [eng] Hyperoxia ; cardiac surgery ; cardiopulmonary bypass
Abstract [eng] Background. Hyperoxia has long been perceived as a desirable or at least an inevitable part of cardiopulmonary bypass. Recent ev- idence suggest that it might have multiple detrimental e ects on patient homeostasis. e aim of the study was to identify the de- terminants of supra-physiological values of partial oxygen pressure during on-pump cardiac surgery and to assess the impact of hyper- oxia on clinical outcomes. Materials and methods. Retrospective data analysis of the in- stitutional research database was performed to evaluate the e ects of hyperoxia in patients undergoing elective cardiac surgery with cardiopulmonary bypass, 246 patients were included in the nal analysis. Patients were divided in three groups: mild hyperoxia (MHO, PaO2 100–199 mmHg), moderate hyperoxia (MdHO, PaO2 200–299 mmHg), and severe hyperoxia (SHO, PaO2 >300 mmHg). Postoperative complications and outcomes were de ned according to standardised criteria of the Society of oracic Surgeons. Results. e extent of hyperoxia was more immense in pa- tients with a lower body mass index (p = 0.001) and of female sex (p = 0.005). A signi cant link between severe hyperoxia and a higher incidence of infectious complications (p – 0.044), an in- creased length of hospital stay (p – 0.044) and extended duration of mechanical ventilation (p < 0.001) was con rmed. Conclusions. Severe hyperoxia is associated with an increased incidence of postoperative infectious complications, prolonged mechanical ventilation, and increased hospital stay.
Published Vilnius : Lietuvos mokslų akademija
Type Journal article
Language English
Publication date 2017
CC license CC license description