Title The role of serum adiponectin for outcome prediction in patients with dilated cardiomyopathy and advanced heart failure
Authors Baltrūnienė, Vaida ; Bironaitė, Daiva ; Kažukauskienė, Ieva ; Bogomolovas, Julijus ; Vitkus, Dalius ; Ručinskas, Kęstutis ; Žurauskas, Edvardas ; Augulis, Renaldas ; Grabauskienė, Virginija
DOI 10.1155/2017/3818292
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Is Part of BioMed research international.. Hindawi. 2017, Vol. 2017, Article ID 3818292, p. [1-13].. ISSN 2314-6133. eISSN 2314-6141
Keywords [eng] Heart failure ; cardiac muscle cells ; patients ; implantation
Abstract [eng] Clinical interpretation of patients’ plasma adiponectin (APN) remains challenging; its value as biomarker in dilated cardiomyopathy (DCM) is equivocal. We evaluated whether circulating APN level is an independent predictor of composite outcome: death, left ventricle assist device (LVAD) implantation, and heart transplantation (HT) in patients with nonischemic DCM. 57 patients with nonischemic DCM (average LV diastolic diameter 6.85 cm, LV ejection fraction 26.63%, and pulmonary capillary wedge pressure 22.06 mmHg) were enrolled. Patients underwent echocardiography, right heart catheterization, and endomyocardial biopsy. During a mean follow-up of 33.42 months, 15 (26%) patients died, 12 (21%) patients underwent HT, and 8 (14%) patients were implantedwith LVAD. APN level was significantly higher in patientswho experienced study endpoints (23.4 versus 10.9 ug/ml, 𝑝 = 0.01).APNwas associated withworse outcome in univariateCox proportional hazardsmodel (HR 1.04, CI 1.02–1.07, 𝑝 = 0.001) but lost significance adjusting for other covariates. Average global strain (AGS) is an independent outcome predictor (HR 1.42, CI 1.081–1.866, 𝑝 = 0.012). Increased circulating APN level was associated with higher mortality and may be an additive prognostic marker in DCM with advanced HF. Combination of serum (APN, BNP, TNF-𝛼) and echocardiographic (AGS) markers may increase the HF predicting power for the nonischemic DCM patients.
Published Hindawi
Type Journal article
Language English
Publication date 2017
CC license CC license description