Daily digital biomarkers in the follow-up and clustering of patients with asthma

Bernardo Sousa-Pinto; Florence Schleich; Gilles Louis; Bilun Gemicioglu; Violeta Kvedarienė; Frederico S Regateiro; Claudia Chaves Loureiro; Luis Taborda-Barata; Rita Amaral; Josep M Antó; Anna Bedbrook; Wienczyslawa Czarlewski; Ignacio J Ansotegui; Karl-C Bergmann; Matteo Bonini; Apostolos Bossios; Louis-Philippe Boulet; Fulvio Braido; Christopher Brightling; Guy Brusselle; Luisa Brussino; G. Walter Canonica; Alvaro A Cruz; Tari Haahtela; Liam G Heaney; Michael Hyland; Juan Carlos Ivancevich; Ludger Klimek; Marek Kulus; Piotr Kuna; Maciej Kupczyk; Desiree E Larenas-Linnemann; Michael Makris; Manuel Marques-Cruz; Sara Gil-Mata; Mário Morais-Almeida; Marek Niedoszytko; Markus Ollert; Nikolaos G Papadopoulos; Vincenzo Patella; Oliver Pfaar; Celeste Porsbjerg; Francesca Puggioni; Santiago Quirce; Carlos Robalo Cordeiro; Nicolas Roche; Boleslaw Samolinski; Joaquin Sastre; Nicola Scichilone; Sabina Skrgat; Sanna Toppila-Salmi; Omar S Usmani; Arūnas Valiulis; Brigita Gradauskienė; Ilgim Vardaloğlu Koyuncu; Maria Teresa Ventura; Rafael José Vieira; Arzu Yorgancioglu; João A Fonseca; Torsten Zuberbier; Benoit Pétré; Renaud Louis; Jean Bousquet

doi:10.1080/25310429.2025.2532980

Title	Daily digital biomarkers in the follow-up and clustering of patients with asthma
Authors	Sousa-Pinto, Bernardo ; Schleich, Florence ; Louis, Gilles ; Gemicioglu, Bilun ; Kvedarienė, Violeta ; Regateiro, Frederico S ; Chaves Loureiro, Claudia ; Taborda-Barata, Luis ; Amaral, Rita ; Antó, Josep M ; Bedbrook, Anna ; Czarlewski, Wienczyslawa ; Ansotegui, Ignacio J ; Bergmann, Karl-C ; Bonini, Matteo ; Bossios, Apostolos ; Boulet, Louis-Philippe ; Braido, Fulvio ; Brightling, Christopher ; Brusselle, Guy ; Brussino, Luisa ; Canonica, G. Walter ; Cruz, Alvaro A ; Haahtela, Tari ; Heaney, Liam G ; Hyland, Michael ; Ivancevich, Juan Carlos ; Klimek, Ludger ; Kulus, Marek ; Kuna, Piotr ; Kupczyk, Maciej ; Larenas-Linnemann, Desiree E ; Makris, Michael ; Marques-Cruz, Manuel ; Gil-Mata, Sara ; Morais-Almeida, Mário ; Niedoszytko, Marek ; Ollert, Markus ; Papadopoulos, Nikolaos G ; Patella, Vincenzo ; Pfaar, Oliver ; Porsbjerg, Celeste ; Puggioni, Francesca ; Quirce, Santiago ; Robalo Cordeiro, Carlos ; Roche, Nicolas ; Samolinski, Boleslaw ; Sastre, Joaquin ; Scichilone, Nicola ; Skrgat, Sabina ; Toppila-Salmi, Sanna ; Usmani, Omar S ; Valiulis, Arūnas ; Gradauskienė, Brigita ; Vardaloğlu Koyuncu, Ilgim ; Ventura, Maria Teresa ; Vieira, Rafael José ; Yorgancioglu, Arzu ; Fonseca, João A ; Zuberbier, Torsten ; Pétré, Benoit ; Louis, Renaud ; Bousquet, Jean
DOI	10.1080/25310429.2025.2532980
Full Text
Is Part of	Pulmonology.. Abingdon : Informa UK Limited. 2025, vol. 31, iss. 1, art. no. 2532980, p. [1-14].. ISSN 2531-0429. eISSN 2531-0437
Keywords [eng]	Asthma ; electronic symptom-medication score ; inhaled corticosteroids ; mHealth ; PROMs
Abstract [eng]	Background and Research question: We aimed to assess whether levels of digital biomarkers can reflect monthly patterns of asthma control Study design and methods: We performed a longitudinal study on patients with asthma and comorbid rhinitis who filled ≥26 days of data in a month in the MASK-air® app and who reported at least 1 day of treatment with an inhaled corticosteroid with or without a long-acting β2-agonist (ICS ± LABA). We applied k-means cluster analysis to define clusters of months according to daily asthma control and medication use. Clusters were compared using digital biomarkers (visual analogue scale [VAS] on asthma symptoms and electronic daily asthma control score [e-DASTHMA]). We compared patients who did not switch with patients who switched their ICS ± LABA. Results: We assessed 243 patients and 1358 months. We identified three clusters of poor asthma control despite high ICS ± LABA adherence, one cluster of poor asthma control and poor ICS ± LABA adherence, one cluster of good asthma control and high ICS ± LABA adherence and one cluster of good asthma control despite poor ICS ± LABA adherence. These clusters displayed relevant differences in VAS asthma and e-DASTHMA levels. Similar clusters were found in ‘non-switchers’ versus ‘switchers’. Conclusion: Levels of digital biomarkers reflect asthma control patterns and might be used to monitor patients with asthma.
Published	Abingdon : Informa UK Limited
Type	Journal article
Language	English
Publication date	2025
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„Daily digital biomarkers in the follow-up and clustering of patients with asthma“