| Abstract [eng] |
Annotation in English During the doctoral studies, systemic literature analysis was performed, describing the topic of metabolism and amino acid homeostasis in critically ill patients during renal replacement therapy. A prospective observational study was organized and successfully completed, during which critically ill patients undergoing renal replacement therapy were studied. During the study, the metabolism of critically ill patients was assessed, and it was found that the study patients were slightly hypocatabolic, had a lower lean body mass index and stress hyperglycemia. Amino acid homeostasis was also assessed: low systemic amino acid concentrations and significant amino acid losses during renal replacement therapy were found. The higher amino acid losses are mainly determined by higher systemic amino acid concentrations, but are also influenced by more intensive renal replacement therapy settings and higher lean body mass. When assessing the clinical outcomes of patients, it was found that the amount of amino acids lost was not associated with clinical outcomes, but association was reported between systemic amino acid concentrations and 30-day mortality in intensive care patients. It was found that higher mortality was observed as systemic amino acid concentrations decreased. |
