| Title |
GLP-1 receptorių agonistų vaidmuo sergant valgymo sutrikimais: apetito reguliavimas ir neurobiologiniai mechanizmai |
| Translation of Title |
The role of GLP-1 receptor agonists in eating disorders: appetite regulation and neurobiological mechanisms. |
| Authors |
Blažytė, Julija ; Strumila, Robertas |
| DOI |
10.15388/NS.2024.28.102.1 |
| Full Text |
|
| Is Part of |
Neurologijos seminarai.. Vilnius : Vilniaus universiteto leidykla. 2024, vol. 28, no. 4(102), p. 219-228.. ISSN 1392-3064. eISSN 2424-5917 |
| Keywords [eng] |
GLP-1 receptor agonists ; eating disorders ; dopamine system ; appetite regulation ; stress-in- duced eating |
| Abstract [eng] |
Eating disorders, such as anorexia nervosa, bulimia nervosa, and binge eating disorder, are often linked to neurobiological dysfunctions, including alterations in dopamine and reward systems. Recent studies suggest that GLP-1 receptor agonists (GLP-1RAs) may have therapeutic effects not only on metabolic disorders but also on psychological conditions. GLP-1 regulates glucose metabolism, suppresses appetite, and influences dopamine signalling in reward pathways, potentially reducing binge eating episodes. Research indicates that GLP-1RAs may decrease stress-related eating by modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing anxiety-driven compulsive food intake. Clinical trials have shown that semaglutide and liraglutide effectively reduce binge-eating symptoms and cravings for high-calorie foods. The effects of GLP-1RAs on binge eating disorder appear to be more significant than those of traditional medications such as SSRIs, topiramate or lisdexamfetamine, though their long-term efficacy remains insufficiently studied. Despite promising results, GLP-1RAs may cause side effects, including gastrointestinal disturbances, hypoglycemia, and potential changes in mental health. Future research should assess their long-term impact and explore possible combinations with other treatment approaches, such as cognitive behavioural therapy. |
| Published |
Vilnius : Vilniaus universiteto leidykla |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2024 |
| CC license |
|
