Title A dosimetric and biological model for neutron capture therapy (NCT) experiments
Authors Kalamara, A ; Stamatelatos, I. E ; Stefanopoulos, K. L ; Kalef-Ezra, J. A ; Georgakilas, A. G ; Stewart, R. D ; Rangos, V ; Knudsen, K. D ; Helgesen, G ; Trtik, P ; Mannes, D ; Hovind, J ; Kaestner, A ; Strobl, M ; Vinš, M ; Klupák, V ; Rabochová, M ; Šoltés, J ; Milčák, J ; Grigalavičius, Mantas ; Theodossiou, T. A
DOI 10.1016/j.apradiso.2025.112233
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Is Part of Applied radiation and isotopes.. Oxford : Elsevier Ltd. 2025, vol. 226, art. no. 112233, p. [1-7].. ISSN 0969-8043. eISSN 1872-9800
Keywords [eng] High LET ; MCDS ; MCNP ; microdosimetry ; neutron capture therapy ; RBE
Abstract [eng] A hybrid Monte Carlo approach using MCNP in combination with the cell-level code Monte Carlo Damage Simulation (MCDS) is presented to support the design and analysis of experiments for the evaluation of gadolinium (Gd) based agents in neutron capture therapy (NCT). Monoenergetic neutrons (0.025 eV–15 MeV) and polyenergetic neutron beams from NEUTRA, ICON (PSI, Switzerland), and HK1 (LVR-15, Czech Republic) were used to estimate the relative biological effectiveness (RBE) of NCT for the biologically critical endpoint of DNA double strand break (DSB) production relative to 60Co γ-rays. Moreover, microdosimetric spectra of protons, electrons, alpha particles and heavy recoils were determined for the aforementioned neutron beams, to enhance the interpretation of energy deposition in subcellular structrures. The proposed, hybrid model and methodology builds on well-validated dosimetry and biophysical models at different spatial scales to create a versatile and generalized framework to estimate dosimetric parameters and RBE. This approach facilitates comparisons between NCT and low linear energy transfer (LET) radiation alternatives.
Published Oxford : Elsevier Ltd
Type Journal article
Language English
Publication date 2025
CC license CC license description