| Title |
Recidyvuojanti Clostridioides difficile infekcija - klinikinio atvejo aprašymas ir literatūros apžvalga |
| Translation of Title |
Recurrent clostridioides difficile infection: a clinical case report and literature review. |
| Authors |
Paulauskas, Mindaugas ; Kunickaitė, Ieva |
| DOI |
10.53453/ms.2025.6.3 |
| Full Text |
|
| Is Part of |
Medicinos mokslai = Journal of medical sciences.. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras. 2025, vol. 13, iss. 4, p. 19-28.. eISSN 2345-0592 |
| Keywords [eng] |
C. difficile clinical case ; pathogenesis ; ribotypes ; treatment |
| Abstract [eng] |
Introduction. Clostridioides difficile (C. difficile) is a Gram-positive, spore-forming anaerobic bacterium and a major cause of antibiotic-associated diarrhea and colitis, particularly in healthcare settings. Ribotyping distinguishes C. difficile strains by variations in the 16S–23S rRNA intergenic region and supports epidemiological tracking. Ribotype 027 (RT027) has been linked to increased virulence and outbreaks. Understanding the clinical significance of ribotypes is essential for improving CDI management and infection control. Aim. To present a clinical case treated at Vilnius University Hospital Santaros Clinics and review literature on C. difficile ribotypes and treatment options. Clinical case. A case of recurrent C. difficile infection is described. Stool tests showed toxins A and B and glutamate dehydrogenase (GDH), while RT027 was not detected. Standard treatment was administered. The case raises the question of whether identifying specific ribotypes could help optimize CDI treatment. Conclusions. C. difficile infection remains a major healthcare concern due to its severe course, frequent recurrences, and growing treatment resistance. Ribotype variability influences not only the spread of infection but also treatment outcomes and disease prognosis. Recognizing hypervirulent ribotypes such as RT027 and RT078/126 is especially important, as they are often associated with more severe disease and higher recurrence rates. |
| Published |
Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2025 |
| CC license |
|
