| Title |
Liver histomorphological changes in first‐ and second‐generation rat offspring associated with maternal undernutrition |
| Authors |
Šimkūnaitė-Rizgelienė, Renata ; Reivytytė, Rosita ; Virbauskytė, Viktorija ; Vosyliūtė, Rūta ; Žalgevičienė, Violeta ; Bartuškienė, Violeta ; Čepulienė, Ramunė ; Tutkuvienė, Janina |
| DOI |
10.1155/cjgh.v2025.1 |
| Full Text |
|
| Is Part of |
Canadian journal of gastroenterology and hepatology.. Hoboken : Wiley. 2025, vol. 2025, art. no. 3752573, p. [1-9].. ISSN 2291-2789. eISSN 2291-2797 |
| Abstract [eng] |
Background: Due topovertyandthepervasivethin-bodyideal,undernutritionposesasigni3cantchallengeinbothdeveloped and economicallyundevelopednations.Maternalnutritionaldeprivationhasbeenlinkedtonegativeoutcomesforthehealthof the fetus,ahigherchanceofmetabolicsyndrome,andadultobesity. Aim: Considering thefunctionsoftheliver,thisstudyaimstoassesstheinterfacebetweenmaternalmalnutritionandmor- phological changesoftheliverinthe3rstandsecondgenerationsofagedo5spring. Methods: 0is experimentalstudyconductedintheDepartmentofAnatomy,Histology,andAnthropologyinvolved26rats divided into3groups:acontrolgroupfedastandarddiet,agroupsubjectedto50%dietaryrestrictionbeforepregnancy,and a groupexperiencing50%dietaryrestrictionbeforeandduringpregnancy.Histopathologicalexaminationwasconductedonthe livers ofboth3rst-andsecond-generationrato5springtoassesstheoccurrenceofhepaticsteatosis,ballooning,in;ammation,and 3brosis. DatacomparisonswereperformedusingtheKruskal–Wallistest. Results: Both the3rst-andsecond-generationexperimentalgroupsdisplayedamorepronouncedsteatosisandballooningindex compared tothecontrolgroup.Inadditiontothis,bothmaleandfemaleprogenyoftheexperimentalgroupsexhibitedhigher levels ofsteatosisandballooning.O5springofmothersundernourishedbeforepregnancydemonstratedamoreseverecaseof steatosis, whereaso5springfrommothersfedalow-caloriedietbeforeandthroughoutpregnancyshowedahigherballooning index. Inthesecondgeneration,thesechangeswerelessprofoundthanthoseseeninthe3rstgeneration.Notably,bothex- perimental groupsofthe3rstgenerationexhibitedsigni3cantlyhigherlevelsofsteatosiscomparedtotheirequivalentsecond- generation counterparts. Conclusions: According tothisstudy,thereisalinkbetweenmaternalundernutritionandahigherriskofnonalcoholic steatohepatitis ornonalcoholicfattyliverdiseaseintheo5spring’slaterlife. |
| Published |
Hoboken : Wiley |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
