| Title |
Shunt surgery for pediatric prehepatic portal hypertension: a single-center case series |
| Authors |
Pikturnaitė, Gabija ; Račytė, Austėja ; Rudokaitė, Alina ; Vaitėnas, Gediminas ; Povilavičius, Jonas ; Prušinskas, Benas ; Dockienė, Ilona ; Kurminas, Marius ; Bernatavičienė, Rūta ; Verkauskas, Gilvydas |
| DOI |
10.3390/jcm14217780 |
| Full Text |
|
| Is Part of |
Journal of clinical medicine.. Basel : MDPI AG. 2025, vol. 14, iss. 21, art. no. 7780, p. [1-10].. eISSN 2077-0383 |
| Keywords [eng] |
long-term results ; Meso-Rex bypass ; prehepatic portal hypertension ; surgical shunts ; variceal bleeding |
| Abstract [eng] |
Background/Objectives: Management of prehepatic portal hypertension involves endoscopic and medical therapies with subsequent shunting if symptoms persist. Lately, surgical shunts, particularly the Meso-Rex shunt, are increasingly considered early in the disease course, offering benefits such as minimized hyperammonemia, improved somatic growth, and preservation of liver function. Our study evaluates post-operative outcomes after different surgical procedures in children with prehepatic portal hypertension. Methods: This single-centre retrospective case series included six children undergoing surgical shunting for prehepatic portal hypertension over a 5-year period. Medical records before and after surgery, followed for an average of 4.0 years, were analyzed. Results: Five patients underwent a Meso-Rex bypass, while one patient underwent a mesorenal shunt procedure. All cases showed clinically significant regression of esophageal varices six months post-surgery. Thrombocyte as well as leukocyte count significantly increased in five out of six patients during the long-term follow-up. Currently, five out of six surgically formed shunts (83%) continue to function normally. Conclusions: Our study supports early surgical intervention for improved long-term outcomes in managing portal hypertension, reducing complications like hypersplenism and variceal bleeding. Early consideration and ongoing monitoring are crucial for long-term success in children with portal hypertension. |
| Published |
Basel : MDPI AG |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
