| Title |
Clinical impact of obsessive-compulsive disorder comorbidity in bipolar disorder: A systematic review and meta-analysis |
| Authors |
De Prisco, Michele ; Tapoi, Cristiana ; Oliva, Vincenzo ; Strumila, Robertas ; Takami, Christine ; Girone, Nicolaja ; MacEllaro, Monica ; De Salles Andrade, Juliana Braga ; Schmitz, Christian Nikolaus ; Vieta, Eduard ; Fico, Giovanna |
| DOI |
10.1192/j.eurpsy.2025.10087 |
| Full Text |
|
| Is Part of |
European psychiatry.. Cambridge : Cambridge University Press. 2025, vol. 68, iss. 1, art. no. e142, p. [1-13].. ISSN 0924-9338. eISSN 1778-3585 |
| Keywords [eng] |
bipolar disorder ; comorbidity ; meta-analysis ; obsessive-compulsive disorder ; suicide |
| Abstract [eng] |
Background Bipolar disorder (BD) is commonly comorbid with other psychiatric conditions, such as obsessive-compulsive disorder (OCD). Despite increasing interest in this comorbidity, quantitative data on its clinical characteristics remain limited. This systematic review and meta-analysis aimed to evaluate the clinical impact of OCD comorbidity in BD by comparing individuals with BD and OCD (BD-OCD) to those with BD without OCD. Methods We systematically searched the PubMed/MEDLINE, Scopus, PsycINFO, and Web of Science databases up to April 15, 2024. Meta-analyses were conducted to compare BD-OCD and BD without OCD groups across multiple clinical domains. Results From 11,959 initial records screened, 26 studies were included in the qualitative synthesis, with 22 eligible for meta-analysis. Individuals with BD-OCD showed higher odds of experiencing chronic mood episodes (OR = 9.42; 95%CI = 2.23, 39.9), rapid cycling (OR = 1.92; 95%CI = 1.04, 3.53), comorbid eating disorders (OR = 3.37; 95%CI = 1.99, 5.7), panic disorder (OR = 3.3; 95%CI = 2.11, 5.2), substance use disorders (OR = 1.39; 95%CI = 1.02, 1.89), and lifetime suicide attempts (OR = 1.85; 95%CI = 1.21, 2.84). Additionally, they presented earlier onset of BD (SMD = -0.27; 95%CI = -0.52, -0.01) and reduced functioning (SMD = -0.42; 95%CI = -0.59, -0.24). Most data were derived from adult populations, limiting the evidence available for children and adolescents. Conclusions BD-OCD presents a more severe and complex clinical profile, requiring specialized assessment and integrated treatment approaches. Identifying these features may support earlier recognition and inform personalized interventions for this population. |
| Published |
Cambridge : Cambridge University Press |
| Type |
Journal article |
| Language |
English |
| Publication date |
2025 |
| CC license |
|
