COVID-19 vaccine effectiveness against hospitalization in older adults, VEBIS hospital network, Europe, September 2024-May 2025

Madelyn Rojas-Castro; Nuno Verdasca; Susana Monge; Laurane De Mot; Camino Trobajo-Sanmartín; Róisín Duffy; Gergő Túri; Monika Kuliešė; Ralf Duerrwald; Maria-Louise Borg; Odette Popovici; Verónica Gomez; Zvjezdana Lovrić Makarić; Odile Launay; Diogo F P Marques; Francisco Pozo; Arne Witdouck; Iván Martínez-Baz; Margaret Fitzgerald; Beatrix Oroszi; Ligita Jančorienė; Silke Buda; Ausra Dziugyte; Mihaela Lazăr; Ausenda Machado; Irena Tabain; Liem Binh Luong Nguyen; Eva Rivas Wagner; François Dufrasne; Jesús Castilla; Lisa Domegan; Viktória Velkey; Fausta Majauskaitė; Carolin Hackmann; Nathalie Nicolay; Sabrina Bacci; Angela M C Rose

doi:10.1111/irv.70191

Title	COVID-19 vaccine effectiveness against hospitalization in older adults, VEBIS hospital network, Europe, September 2024-May 2025
Authors	Rojas-Castro, Madelyn ; Verdasca, Nuno ; Monge, Susana ; De Mot, Laurane ; Trobajo-Sanmartín, Camino ; Duffy, Róisín ; Túri, Gergő ; Kuliešė, Monika ; Duerrwald, Ralf ; Borg, Maria-Louise ; Popovici, Odette ; Gomez, Verónica ; Makarić, Zvjezdana Lovrić ; Launay, Odile ; Marques, Diogo F P ; Pozo, Francisco ; Witdouck, Arne ; Martínez-Baz, Iván ; Fitzgerald, Margaret ; Oroszi, Beatrix ; Jančorienė, Ligita ; Buda, Silke ; Dziugyte, Ausra ; Lazăr, Mihaela ; Machado, Ausenda ; Tabain, Irena ; Nguyen, Liem Binh Luong ; Wagner, Eva Rivas ; Dufrasne, François ; Castilla, Jesús ; Domegan, Lisa ; Velkey, Viktória ; Majauskaitė, Fausta ; Hackmann, Carolin ; Nicolay, Nathalie ; Bacci, Sabrina ; Rose, Angela M C
DOI	10.1111/irv.70191
Full Text
Is Part of	Influenza and other respiratory viruses.. Hoboken : Wiley. 2025, vol. 19, iss. 11, art. no. e70191, p. [1-8].. ISSN 1750-2640. eISSN 1750-2659
Keywords [eng]	case–control study ; elderly ; severe acute respiratory infection (SARI) ; test‐negative design ; vaccine effectiveness
Abstract [eng]	We estimated COVID-19 vaccine effectiveness (VE) against PCR-confirmed SARS-CoV-2 hospitalization in patients ≥ 60 years with severe acute respiratory infection, using a multicenter, test-negative, case-control study across seven sites in six European countries between September 2024 and May 2025. We included 352 cases (115 vaccinated; 33%) and 9980 controls (5024 vaccinated; 50%). VE was 42% (95% CI: 15; 61) 14-59 days post-vaccination, 32% (95% CI: -1; 54) at 60-119 days, and 36% (95% CI: 2; 60) at 120-179 days, and no effect thereafter. Among adults aged 60-79 and ≥ 80 years, we observed moderate VE against COVID-19 hospitalization for up to 2 and 4 months, respectively.
Published	Hoboken : Wiley
Type	Journal article
Language	English
Publication date	2025
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„COVID-19 vaccine effectiveness against hospitalization in older adults, VEBIS hospital network, Europe, September 2024-May 2025“