Title Genome-wide association study of 398,238 women unveils seven loci associated with high-grade serous ovarian cancer
Authors Barnes, Daniel R ; Tyrer, Jonathan P ; Dennis, Joe ; Leslie, Goska ; Bolla, Manjeet K ; Lush, Michael ; Aeilts, Amber M ; Aittomäki, Kristiina ; Andrieu, Nadine ; Andrulis, Irene L ; Anton-Culver, Hoda ; Arason, Adalgeir ; Arun, Banu K ; Balmaña, Judith ; Bandera, Elisa V ; Barkardottir, Rosa B ; Berger, Lieke P. V ; Berrington de Gonzalez, Amy ; Berthet, Pascaline ; Białkowska, Katarzyna ; Bjørge, Line ; Blanco, Amie M ; Blok, Marinus J ; Bobolis, Kristie A ; Bogdanova, Natalia V ; Brenton, James D ; Butz, Henriett ; Buys, Saundra S ; Caligo, Maria A ; Campbell, Ian ; Castillo, Carmen ; Claes, Kathleen B. M ; Colonna, Sarah V ; Cook, Linda S ; Daly, Mary B ; Dansonka-Mieszkowska, Agnieszka ; de la Hoya, Miguel ; deFazio, Anna ; DePersia, Allison ; Ding, Yuan Chun ; Doherty, Jennifer A ; Domchek, Susan M ; Dörk, Thilo ; Einbeigi, Zakaria ; Engel, Christoph ; Evans, D. Gareth ; Foretova, Lenka ; Fortner, Renée T ; Fostira, Florentia ; Foti, Maria Cristina ; Friedman, Eitan ; Frone, Megan N ; Ganz, Patricia A ; Gentry-Maharaj, Aleksandra ; Glendon, Gord ; Godwin, Andrew K ; González-Neira, Anna ; Greene, Mark H ; Gronwald, Jacek ; Guerrieri-Gonzaga, Aliana ; Hamann, Ute ; Hansen, Thomas V. O ; Harris, Holly R ; Hauke, Jan ; Heitz, Florian ; Hogervorst, Frans B. L ; Hooning, Maartje J ; Hopper, John L ; Huff, Chad D ; Huntsman, David G ; Imyanitov, Evgeny N ; Izatt, Louise ; Jakubowska, Anna ; James, Paul A ; Janavičius, Ramūnas ; John, Esther M ; Kar, Siddhartha ; Karlan, Beth Y ; Kennedy, Catherine J ; Kiemeney, Lambertus A.L.M ; Konstantopoulou, Irene ; Kupryjanczyk, Jolanta ; Laitman, Yael ; Lavie, Ofer ; Lawrenson, Kate ; Lester, Jenny ; Lesueur, Fabienne ; Lopez-Pleguezuelos, Carlos ; Mai, Phuong L ; Manoukian, Siranoush ; May, Taymaa ; McNeish, Iain A ; Menon, Usha ; Milne, Roger L ; Modugno, Francesmary ; Mongiovi, Jennifer M ; Montagna, Marco ; Moysich, Kirsten B ; Neuhausen, Susan L ; Nielsen, Finn C ; Noguès, Catherine ; Oláh, Edit ; Olopade, Olufunmilayo I ; Osorio, Ana ; Papi, Laura ; Pathak, Harsh ; Pearce, Celeste L ; Pedersen, Inge S ; Peixoto, Ana ; Pejovic, Tanja ; Peng, Pei-Chen ; Peshkin, Beth N ; Peterlongo, Paolo ; Powell, C. Bethan ; Prokofyeva, Darya ; Pujana, Miquel Angel ; Radice, Paolo ; Rashid, Muhammad U ; Rennert, Gad ; Richenberg, George ; Sandler, Dale P ; Sasamoto, Naoko ; Setiawan, Veronica W ; Sharma, Priyanka ; Sieh, Weiva ; Singer, Christian F ; Snape, Katie ; Sokolenko, Anna P ; Soucy, Penny ; Southey, Melissa C ; Stoppa-Lyonnet, Dominique ; Sutphen, Rebecca ; Sutter, Christian ; Tan, Yen Y ; Teixeira, Manuel R ; Terry, Kathryn L ; Thomsen, Liv Cecilie V ; Tischkowitz, Marc ; Toland, Amanda E ; Van Gorp, Toon ; Vega, Ana ; Velez Edwards, Digna R ; Webb, Penelope M ; Weitzel, Jeffrey N ; Wentzensen, Nicolas ; Whittemore, Alice S ; Winham, Stacey J ; Wu, Anna H ; Yadav, Siddhartha ; Yu, Yao ; Ziogas, Argyrios ; Berchuck, Andrew ; Couch, Fergus J ; Goode, Ellen L ; Goodman, Marc T ; Monteiro, Alvaro N ; Offit, Kenneth ; Ramus, Susan J ; Risch, Harvey A ; Schildkraut, Joellen M ; Thomassen, Mads ; Simard, Jacques ; Easton, Douglas F ; Jones, Michelle R ; Chenevix-Trench, Georgia ; Gayther, Simon A ; Antoniou, Antonis C ; Pharoah, Paul D. P
DOI 10.1038/s41525-025-00529-w
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Is Part of npj Genomic Medicine.. Nature Research. 2025, vol. 10, art. no. 73, p. 1-21.. eISSN 2056-7944
Abstract [eng] Nineteen genomic regions have been associated with high-grade serous ovarian cancer (HGSOC). We meta-analyzed >22 million variants for 398,238 women from the Ovarian Cancer Association Consortium (OCAC), UK Biobank (UKBB) and Consortium of Investigators of Modifiers of BRCA1/BRCA2 (CIMBA) to identify novel HGSOC susceptibility loci. Eight novel variants were associated with HGSOC risk. An interesting discovery biologically was TP53 3’-UTR SNP rs78378222-T’s association with HGSOC (per-T-allele relative risk (RR) = 1.44, 95% CI:1.28–1.62, P = 1.76 × 10−9). Polygenic scores (PGS) were developed using OCAC and CIMBA data and trained on FinnGen data. The optimal PGS included 64,518 variants and was associated with an odds ratio of 1.46 (95% CI:1.37–1.54) per standard deviation when validated in the UKBB. This study represents the largest HGSOC GWAS to date – demonstrating that improvements in imputation reference panels and increased sample sizes help to identify HGSOC associated variants that previously went undetected, ultimately improving PGS which can improve personalized HGSOC risk prediction.
Published Nature Research
Type Journal article
Language English
Publication date 2025
CC license CC license description