| Title |
Molecular mechanisms of quinone and polyphenol induced mouse hepatoma cell death / |
| Translation of Title |
Molekuliniai chinonų ir polifenolių sukeltos pelės hepatomos ląstelių žūties mechanizmai. |
| Authors |
Jarašienė-Burinskaja, Rasa |
| Full Text |
|
| Pages |
32 |
| Keywords [eng] |
Quinones ; polyphenols ; cytotoxicity ; oxidative stresschemotherapy |
| Abstract [eng] |
Quinones and polyphenols are biologically active compounds that are widely abundant in nature. They take part in various physiological processes in living organisms. For several decades now, the anti-cancer effects of these compounds were known, but their mechanisms of activity remain unclear even with substantial research being carried out. The goal of this work was to determine the possible activity mechanisms of aziridinyl-substituted benzoquinone (RH1; 2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone) and polyphenol quercetin (QUE; 3,3,4,5,7-pentahydroxyflavine) in a mouse hepatoma tumour cell line. The main focus in this work is on the intracellular signalling pathways activated during the induction of cell death via these compounds. We established links between the structure and cytotoxicity of the quinones and polyphenols as well as the roles of oxidative stress and bioreductive activation in inducing apoptosis and the formation of DNA damage in the cells. Mitogen-activated protein kinase (MAPK) and transcription factor p53 signalling pathways were investigated for the first time in cells treated with RH1 and QUE. The results are relevant to possible future prospects of using aziridinyl-benzoquinones for tumour. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2018 |
