| Title |
Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging / |
| Authors |
Oh, Gabriel ; Ebrahimi, Sasha ; Carlucci, Matthew ; Zhang, Aiping ; Nair, Akhil ; Groot, Daniel E ; Labrie, Viviane ; Jia, Peixin ; Oh, Edward S ; Jeremian, Richie H ; Susic, Miki ; Shrestha, Tenjin C ; Ralph, Martin R ; Gordevičius, Juozas ; Koncevičius, Karolis ; Petronis, Artūras |
| DOI |
10.1038/s41467-018-03073-7 |
| Full Text |
|
| Is Part of |
Nature communications.. London : Nature Publishing Group. 2018, Vol. 9, art. no. 644, p. 1-11.. ISSN 2041-1723 |
| Keywords [eng] |
DNA methylation ; gene-expression ; c-Myc ; disease ; clock ; mammals ; protein ; 5-hydroxymethylcytosine ; 5-methylcytosine ; transcription |
| Abstract [eng] |
Circadian rhythmicity governs a remarkable array of fundamental biological functions and is mediated by cyclical transcriptomic and proteomic activities. Epigenetic factors are also involved in this circadian machinery; however, despite extensive efforts, detection and characterization of circadian cytosine modifications at the nucleotide level have remained elusive. In this study, we report that a large proportion of epigenetically variable cytosines show a circadian pattern in their modification status in mice. Importantly, the cytosines with circadian epigenetic oscillations significantly overlap with the cytosines exhibiting age-related changes in their modification status. Our findings suggest that evolutionary advantageous processes such as circadian rhythmicity can also contribute to an organism's deterioration. |
| Published |
London : Nature Publishing Group |
| Type |
Journal article |
| Language |
English |
| Publication date |
2018 |
