Allergic Rhinitis and its Impact on Asthma (ARIA)‐ EAACI guidelines—2024–2025 revision: Part II —guidelines on oral and ocular treatments

Rafael José Vieira; Bernardo Sousa‐Pinto; Jean Bousquet; Holger J Schünemann; Torsten Zuberbier; Antonio Bognanni; Alkis Togias; Boleslaw Samolinski; Arūnas Valiulis; Sian Williams; Anna Bedbrook; Wienczyslawa Czarlewski; Maria Jose Torres; Mohamed H Shamji; Mário Morais‐Almeida; G. Walter Canonica; Leticia de las Vecillas; Mark S Dykewicz; Cristina Jacomelli; Ludger Klimek; Lucas Leemann; Olga Lourenço; Nikolaos G Papadopoulos; Ana Margarida Pereira; Marine Savouré; Sanna K Toppila‐Salmi; Maria Teresa Ventura; Juan José Yepes‐Nuñez; Alvaro A Cruz; Giorgio Ciprandi; Bilun Gemicioglu; Mattia Giovannini; Brigita Gradauskienė; Tuomas Jartti; Miloš Jeseňák; Piotr Kuna; Violeta Kvedarienė; Désirée E Larenas‐Linnemann; Amir H. A Latiff; Yousser Mohammad; Ken Ohta; Padukudru A Mahesh; Isabella Pali‐Schöll; Oliver Pfaar; Frederico S Regateiro; Nicolas Roche; Luís Taborda‐Barata; Charlotte Suppli Ulrik; Giovanni Viegi; Luo Zhang; Tari Haahtela; Ivan Cherrez‐Ojeda; Juan Carlos Ivancevich; Nikolai Khaltaev; Arzu Yorgancioglu; Baharudin Abdullah; Mona Al‐Ahmad; Maryam Ali Al‐Nesf; Rita Amaral; Julijana Asllani; Karl‐C Bergmann; Jonathan A Bernstein; Michael S Blaiss; Elina Toskala; Pedro Carreiro‐Martins; Thomas Casale; Lorenzo Cecchi; Alessandro Fiocchi; Antonio F. M Giuliano; George Christoff; Ieva Cirule; Jaime Correia de Sousa; Elisio M Costa; Philippe Devillier; Elham Hossny; Tomohisa Iinuma; Zhanat Ispayeva; Kaja Julge; Igor Kaidashev; Kazi S Bennoor; Helga Kraxner; Inger Kull; Marek Kulus; Maciej Kupczyk; Andriy Kurchenko; Stefania La Grutta; Neven Miculinic; Lan Le Thi Tuyet; Sang Min Lee; Stephen Montefort; Andre Moreira; Joaquim Mullol; Rachel Nadif; Alla Nakonechna; Hugo E Neffen; Marek Niedoszytko; Robyn E O'Hehir; Ismail Ogulur; Yoshitaka Okamoto; Heidi Olze; Oscar Palomares; Petr Panzner; Vincenzo Patella; Constantinos Pitsios; Francesca Puggioni; Santiago Quirce; Agnė Ramonaitė; Maria Susana Repka‐Ramirez; Graham Roberts; Karla Robles‐Velasco; Menachem Rottem; Marianella Salapatas; Joaquin Sastre; Nicola Scichilone; Juan‐Carlos Sisul; Dirceu Solé; Manuel E Soto‐Martinez; Milan Sova; Pongsakorn Tantilipikorn; Ana Todo‐Bom; Vladyslav Tsaryk; Ioanna Tsiligianni; Marilyn Urrutia‐Pereira; Erkka Valovirta; Tuula Vasankari; Dana Wallace; De Yun Wang; Margitta Worm; Osman M Yusuf; Sara Gil‐Mata; Manuel Marques‐Cruz; Bassam Mahboub; Antonino Romano; Werner Aberer; Maria Cristina Artesani; Elena Azzolini; Bruno Barreto; Joan Bartra; Sven Becker; Bianca Beghe; Attilio Boner; Ewa Borowiack; Jacques Bouchard; Luisa Brussino; Roland Buhl; Francesco Catamerò; Denis Charpin; Niels H Chavannes; Marta Chełmińska; Lei Cheng; Ekaterine Chkhartishvili; Seong H Cho; Herberto Jose Chong‐Neto; Derek K Chu; Cemal Cingi; Enrico Compalati; Raquel Albuquerque Costa; Biljana Cvetkovski; Victoria Cardona; Gennaro D'Amato; Janet M Davies; Danilo Di Bona; Sandra N Gonzalez Diaz; Maria V Dimou; Maria Doulaptsi; Renato Ferreira‐da‐Silva; Radoslaw Gawlik; Mario Calvo‐Gil; Maximiliano R Gómez; Maia Gotua; Christos Grigoreas; Maria Antonieta Guzman; Rachel House; Michael Hyland; Despo Ierodiakonou; Aspasia Karavelia; Paul Keith; Marta Kisiel; Tanja Soklic Kosak; Mitja Kosnik; Ilgim Vardaloglu Koyuncu; Vicky Kritikos; Justyna Litynska; Carlo Lombardi; Gilles Louis; Xin Luo; Matteo Martini; Cem Meço; Eris Mesonjesi; Florin Mihaltan; Marcin Moniuszko; Robert N Naclerio; Sophia Neisinger; Markus Ollert; Michal Ordak; Giovanni Paoletti; Elena Parmelli; Edgar Arturo Perdomo‐Flores; Henrique Pereira; José Miguel Fuentes Pérez; Nhan Pham‐Thi; Emmanuel Prokopakis; Inês Ribeiro‐Vaz; Giovanni Rolla; Jan Romantowski; Philippe Rombaux; Philip W Rouadi; Dermot Ryan; Ewelina Sadowska; Daiju Sakurai; Laila Salameh; Elie Serrano; Jane Da Silva; Michael B Soyka; Krzysztof Specjalski; Vesna Tomic‐Spiric; Katarina Stevanovic; Abirami Subramaniam; Tuuli Thomander; Wu Tong; Martina Vachova; Marianne van Hage; Martin Wagenmann; Fanny Wai San Ko; Pascal Werminghaus; Paraskevi Vicky Xepapadaki; Yi‐Kui Xiang; Qintai Yang; He Zhang; Jaron Zuberbier; João A Fonseca

doi:10.1111/all.70305

Title	Allergic Rhinitis and its Impact on Asthma (ARIA)‐ EAACI guidelines—2024–2025 revision: Part II —guidelines on oral and ocular treatments
Authors	Vieira, Rafael José ; Sousa‐Pinto, Bernardo ; Bousquet, Jean ; Schünemann, Holger J ; Zuberbier, Torsten ; Bognanni, Antonio ; Togias, Alkis ; Samolinski, Boleslaw ; Valiulis, Arūnas ; Williams, Sian ; Bedbrook, Anna ; Czarlewski, Wienczyslawa ; Torres, Maria Jose ; Shamji, Mohamed H ; Morais‐Almeida, Mário ; Canonica, G. Walter ; Vecillas, Leticia de las ; Dykewicz, Mark S ; Jacomelli, Cristina ; Klimek, Ludger ; Leemann, Lucas ; Lourenço, Olga ; Papadopoulos, Nikolaos G ; Pereira, Ana Margarida ; Savouré, Marine ; Toppila‐Salmi, Sanna K ; Ventura, Maria Teresa ; Yepes‐Nuñez, Juan José ; Cruz, Alvaro A ; Ciprandi, Giorgio ; Gemicioglu, Bilun ; Giovannini, Mattia ; Gradauskienė, Brigita ; Jartti, Tuomas ; Jeseňák, Miloš ; Kuna, Piotr ; Kvedarienė, Violeta ; Larenas‐Linnemann, Désirée E ; Latiff, Amir H. A ; Mohammad, Yousser ; Ohta, Ken ; Mahesh, Padukudru A ; Pali‐Schöll, Isabella ; Pfaar, Oliver ; Regateiro, Frederico S ; Roche, Nicolas ; Taborda‐Barata, Luís ; Ulrik, Charlotte Suppli ; Viegi, Giovanni ; Zhang, Luo ; Haahtela, Tari ; Cherrez‐Ojeda, Ivan ; Ivancevich, Juan Carlos ; Khaltaev, Nikolai ; Yorgancioglu, Arzu ; Abdullah, Baharudin ; Al‐Ahmad, Mona ; Al‐Nesf, Maryam Ali ; Amaral, Rita ; Asllani, Julijana ; Bergmann, Karl‐C ; Bernstein, Jonathan A ; Blaiss, Michael S ; Toskala, Elina ; Carreiro‐Martins, Pedro ; Casale, Thomas ; Cecchi, Lorenzo ; Fiocchi, Alessandro ; Giuliano, Antonio F. M ; Christoff, George ; Cirule, Ieva ; de Sousa, Jaime Correia ; Costa, Elisio M ; Devillier, Philippe ; Hossny, Elham ; Iinuma, Tomohisa ; Ispayeva, Zhanat ; Julge, Kaja ; Kaidashev, Igor ; Bennoor, Kazi S ; Kraxner, Helga ; Kull, Inger ; Kulus, Marek ; Kupczyk, Maciej ; Kurchenko, Andriy ; La Grutta, Stefania ; Miculinic, Neven ; Tuyet, Lan Le Thi ; Lee, Sang Min ; Montefort, Stephen ; Moreira, Andre ; Mullol, Joaquim ; Nadif, Rachel ; Nakonechna, Alla ; Neffen, Hugo E ; Niedoszytko, Marek ; O'Hehir, Robyn E ; Ogulur, Ismail ; Okamoto, Yoshitaka ; Olze, Heidi ; Palomares, Oscar ; Panzner, Petr ; Patella, Vincenzo ; Pitsios, Constantinos ; Puggioni, Francesca ; Quirce, Santiago ; Ramonaitė, Agnė ; Repka‐Ramirez, Maria Susana ; Roberts, Graham ; Robles‐Velasco, Karla ; Rottem, Menachem ; Salapatas, Marianella ; Sastre, Joaquin ; Scichilone, Nicola ; Sisul, Juan‐Carlos ; Solé, Dirceu ; Soto‐Martinez, Manuel E ; Sova, Milan ; Tantilipikorn, Pongsakorn ; Todo‐Bom, Ana ; Tsaryk, Vladyslav ; Tsiligianni, Ioanna ; Urrutia‐Pereira, Marilyn ; Valovirta, Erkka ; Vasankari, Tuula ; Wallace, Dana ; Wang, De Yun ; Worm, Margitta ; Yusuf, Osman M ; Gil‐Mata, Sara ; Marques‐Cruz, Manuel ; Mahboub, Bassam ; Romano, Antonino ; Aberer, Werner ; Artesani, Maria Cristina ; Azzolini, Elena ; Barreto, Bruno ; Bartra, Joan ; Becker, Sven ; Beghe, Bianca ; Boner, Attilio ; Borowiack, Ewa ; Bouchard, Jacques ; Brussino, Luisa ; Buhl, Roland ; Catamerò, Francesco ; Charpin, Denis ; Chavannes, Niels H ; Chełmińska, Marta ; Cheng, Lei ; Chkhartishvili, Ekaterine ; Cho, Seong H ; Chong‐Neto, Herberto Jose ; Chu, Derek K ; Cingi, Cemal ; Compalati, Enrico ; Costa, Raquel Albuquerque ; Cvetkovski, Biljana ; Cardona, Victoria ; D'Amato, Gennaro ; Davies, Janet M ; Di Bona, Danilo ; Gonzalez Diaz, Sandra N ; Dimou, Maria V ; Doulaptsi, Maria ; Ferreira‐da‐Silva, Renato ; Gawlik, Radoslaw ; Calvo‐Gil, Mario ; Gómez, Maximiliano R ; Gotua, Maia ; Grigoreas, Christos ; Guzman, Maria Antonieta ; House, Rachel ; Hyland, Michael ; Ierodiakonou, Despo ; Karavelia, Aspasia ; Keith, Paul ; Kisiel, Marta ; Kosak, Tanja Soklic ; Kosnik, Mitja ; Koyuncu, Ilgim Vardaloglu ; Kritikos, Vicky ; Litynska, Justyna ; Lombardi, Carlo ; Louis, Gilles ; Luo, Xin ; Martini, Matteo ; Meço, Cem ; Mesonjesi, Eris ; Mihaltan, Florin ; Moniuszko, Marcin ; Naclerio, Robert N ; Neisinger, Sophia ; Ollert, Markus ; Ordak, Michal ; Paoletti, Giovanni ; Parmelli, Elena ; Perdomo‐Flores, Edgar Arturo ; Pereira, Henrique ; Pérez, José Miguel Fuentes ; Pham‐Thi, Nhan ; Prokopakis, Emmanuel ; Ribeiro‐Vaz, Inês ; Rolla, Giovanni ; Romantowski, Jan ; Rombaux, Philippe ; Rouadi, Philip W ; Ryan, Dermot ; Sadowska, Ewelina ; Sakurai, Daiju ; Salameh, Laila ; Serrano, Elie ; Da Silva, Jane ; Soyka, Michael B ; Specjalski, Krzysztof ; Tomic‐Spiric, Vesna ; Stevanovic, Katarina ; Subramaniam, Abirami ; Thomander, Tuuli ; Tong, Wu ; Vachova, Martina ; van Hage, Marianne ; Wagenmann, Martin ; Ko, Fanny Wai San ; Werminghaus, Pascal ; Xepapadaki, Paraskevi Vicky ; Xiang, Yi‐Kui ; Yang, Qintai ; Zhang, He ; Zuberbier, Jaron ; Fonseca, João A
DOI	10.1111/all.70305
Full Text
Is Part of	Allergy.. Hoboken : Wiley. 2026, Early Access, p. [1-24].. ISSN 0105-4538. eISSN 1398-9995
Keywords [eng]	allergic rhinitis ; guidelines ; leukotriene receptor antagonists ; ocular antihistamines ; oral antihistamines
Abstract [eng]	ABSTRACT Background: Oral and ocular medications are frequently used in the treatment of allergic rhinitis (AR). As part of the update of the Allergic Rhinitis and its Impact on Asthma (ARIA)-EAACI guidelines, this manuscript presents the ARIA-EAACI 2024–2025 recommendations for oral and ocular treatments. Methods: The ARIA-EAACI 2024–2025 guideline panel issued recommendations following the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) evidence-to-decision framework. Several sources of evidence were used to inform panel judgements and recommendations, including systematic reviews, mHealth and pharmacovigilance data as well as a survey on costs. Results: Eight guideline questions concerning oral treatments for AR and three questions concerning ocular treatments were addressed. These questions led to the recommendations. Overall, these questions concern the choice between different classes of medication. They also discuss the role of oral antihistamines (OAH), leukotriene receptor antagonists (LTRA), ocular antihistamines (OcAH) and ocular mast cell stabilisers. Four questions had not been previously evaluated in ARIA guidelines, while, for the other four, there was a change in the strength or directionality of the recommendations. Overall, these guidelines recommend using intranasal corticosteroids over OAH and using OAH over LTRA. Moreover, they suggest using OAH over OcAH and suggest being against adding LTRA to OAH. Finally, considerations for choosing between different individual OAHs are presented. Conclusion: This ARIA-EAACI 2024–2025 article supports patients, their caregivers and healthcare professionals in choosing oral and ocular treatments for AR. Decisions on treatment should consider the clinical variability of the disease, patients' values and the affordability of medications.
Published	Hoboken : Wiley
Type	Journal article
Language	English
Publication date	2026
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„Allergic Rhinitis and its Impact on Asthma (ARIA)‐ EAACI guidelines—2024–2025 revision: Part II —guidelines on oral and ocular treatments“