| Title |
Skin-limited Langerhans cell histiocytosis in an adult |
| Authors |
Guobytė, Neringa ; Šerpytienė, Emilija ; Macejevska, Monika Marta ; Krivickaitė, Milda ; Grigaitienė, Jūratė |
| DOI |
10.4081/dr.2021.9102 |
| Full Text |
|
| Is Part of |
Dermatology reports.. Pavia : PAGEPress Publications. 2026, vol. 18, iss. 1, art. no. 9102, p. [1-3].. ISSN 2036-7392. eISSN 2036-7406 |
| Keywords [eng] |
skin-limited ; Langerhans cell histiocytosis ; CD1a ; S100 ; adult |
| Abstract [eng] |
Langerhans cell histiocytosis (LCH) is an idiopathic group of disorders characterized histologically by proliferation and infiltration of tissue by Langerhans cell-type histiocytes. This disease can affect various organs. Patients with a single system lesion should be followed carefully. Detection of somatic BRAF-V600E mutation in circulating blood cells or in lesional biopsies has been associated with high-risk clinical characteristics. A 38-year-old male presented to our Dermatology Centre with a 3-month history of a small nodule on his right leg skin. Surgery to remove the lesion was performed. The diagnosis of skin-limited LCH was established. Due to possible systemic spread, the patient was referred to a hematologist for further evaluation. A full-body computed tomography (CT) scan did not show any infiltrates in other organs. Bone marrow aspirate and biopsy were performed; no Langerhans cells were detected. Sometimes skin lesions may represent the most clinically evident manifestation of potentially life-threatening multisystem disease. |
| Published |
Pavia : PAGEPress Publications |
| Type |
Journal article |
| Language |
English |
| Publication date |
2026 |
| CC license |
|
