| Title |
Hiperurikemijos ir glikeminių rodiklių ryšys metaboliniu sindromu sergančių pacientų grupėje: retrospektyvinis tyrimas |
| Translation of Title |
The relationship between hyperuricemia and glycemic markers in patients with metabolic syndrome: a retrospective study. |
| Authors |
Ruzgytė, Ieva ; Dadonienė, Jolanta |
| DOI |
10.53453/ms.2026.4.9 |
| Full Text |
|
| Is Part of |
Medicinos mokslai = Journal of medical sciences.. Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras. 2026, vol. 14, iss. 2, p. 88-96.. eISSN 2345-0592 |
| Keywords [eng] |
hyperuricemia ; fasting glucose ; glycated hemoglobin ; diabetes mellitus ; metabolic syndrome |
| Abstract [eng] |
Introduction. Hyperuricemia (HU), defined as a chronic elevation of serum uric acid (UA), is common in patients with metabolic syndrome and has been linked to insulin resistance and hyperglycemia. Although HU may increase the risk of type 2 diabetes mellitus (DM), its relationship with glycemic markers remains unclear. Aim. To evaluate the association between HU and glycemic parameters in patients with metabolic syndrome. Materials and Methods. A retrospective cross-sectional study was conducted using an anonymized database of 238 patients (85 men, 153 women). Variables analyzed included UA, fasting plasma glucose, glycated hemoglobin (HbA1c), and DM status. Associations were assessed using Spearman’s correlation and univariate linear regression. Statistical significance was set at p < 0.05. A literature review was performed using PubMed and Google Scholar. Results. Men had higher UA levels than women (491.9 ± 46.9 vs. 409.0 μmol/L; p < 0.001). In the total sample, UA did not correlate with fasting glucose, HbA1c, or DM. In men, UA was positively associated only with fasting glucose (B = 12.83; p = 0.013). In women, UA correlated with fasting glucose (ρ = 0.161; p = 0.047) and DM (ρ = 0.193; p = 0.032). Among women with DM, median UA was higher than in those without DM (430 vs. 396 μmol/L; p = 0.032). Conclusions. UA is associated with DM only in women and with fasting glucose in both sexes when analyzed separately. No significant association was observed between UA and HbA1c. |
| Published |
Kėdainiai : VšĮ Lietuvos sveikatos mokslinių tyrimų centras |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2026 |
| CC license |
|
