Title Cardiovascular risk profile of patients with atherogenic dyslipidemia in middle age Lithuanian population /
Authors Kutkienė, Sandra ; Petrulionienė, Žaneta ; Laucevičius, Aleksandras ; Matuzevičienė, Gabija ; Kasiulevičius, Vytautas ; Petrulionytė, Emilija ; Staigytė, Justina ; Šaulytė, Akvilė ; Gargalskaitė, Urtė ; Skiauterytė, Eglė ; Kovaitė, Milda ; Rinkūnienė, Egidija
DOI 10.1186/s12944-018-0851-0
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Is Part of Lipids in health and disease.. London : BioMed Central Ltd. 2018, vol. 17, art. no 208, p. 1-7.. ISSN 1476-511X. eISSN 1476-511X
Keywords [eng] atherogenic dyslipidemia ; hypertriglyceridemia ; low-HDL cholesterol ; cardiovascular risk profile
Abstract [eng] Background: Atherogenic dyslipidemia (AD) is a blood serum lipid profile abnormality characterized by elevation of triglycerides and reduced levels of high density lipoprotein cholesterol (HDL-C). It is associated with residual cardiovascular risk. This study evaluated and compared the risk profiles of patients with hypertriglyceridemia, low- HDL-C levels or AD, in order to understand, which lipid profile is associated with greater risk. Methods: During the period of 2009–2016 a population of 92,373 Lithuanian adults (men 40–54 years old and women 50–64 years old) without overt cardiovascular disease were analyzed. Data of 25,746 patients (68.6% women and 31.4% men) with hypertriglyceridemia and/or low HDL-C low levels were collected and used for further statistical analysis. Results: Participants with AD tend to have more unfavorable risk profile than participants with hypertriglyceridemia or low-HDL-C. AD tends to cluster with other atherogenic risk factors, such as arterial hypertension [odds ratio (OR) 1.96, 95% confidence intervals (CI) 1.87–2.01], smoking [OR 1.20, 95% CI 1.14–1.27], diabetes mellitus [OR 2.74, 95% CI 2.58–2.90], obesity [OR 2.92, 95% CI 2.78–3.10], metabolic syndrome [OR 22.27, 95% CI 20.69–23.97], unbalanced diet [OR 1,59, 95% CI 1.51–1.68], low physical activity [OR 1.80, 95% CI 1.71–1,89], CHD history in first degree relatives [OR 1.18, 95% CI 1.12–1.25] and total number of risk factors [OR 1.47, 95% CI 1.38–1.57]. Conclusion: AD is associated with more unfavorable cardiovascular risk profile than hypertriglyceridemia or low- HDL cholesterol levels. Once identified AD should require additional medical attention since it is an important factor of residual cardiovascular risk.
Published London : BioMed Central Ltd
Type Journal article
Language English
Publication date 2018