| Abstract [eng] |
Introduction. Hypothermic oxygenated machine perfusion is an innovative and rapidly adopted organ preservation method designed to enhance the quality of donor livers and reduce their risk of unsuitability for transplantation. The significance of this method is driven by the persistent shortage of donor livers and the need to optimize transplantation outcomes, particularly when using extended- criteria donor organs. Hypothermic oxygenated machine perfusion technology allows safer utilization of extended-criteria donor livers, reduces the extent of ischemia–reperfusion injury, and improves both early and long-term postoperative outcomes for recipients. Study Aim. To evaluate the early outcomes of liver transplantations performed at Vilnius University Hospital Santaros Klinikos in 2022–2025, during which hypothermic oxygenated machine liver perfusion was applied, to present the center’s results, and to conduct a review of the scientific literature. Results. During the period 2022–2025, 50 liver transplants were performed at Vilnius University Hospital Santaros Klinikos, of which 20% (n=10) were performed using hypothermic oxygenated machine perfusion. All donors met extended criteria, and according to the type of donation, most organs were obtained after brain death. In the recipient group, men made up the majority (n=6, 60%), and the average age was 46.1 years. The average waiting time before transplantation was 276 ± 225.8 days, and the MELD score on the day of transplantation was 24 ± 4.8 points. The main indication for transplantation was metabolic cirrhosis (n= 4, 36.4%). The average duration of the operation was 425 ± 116.5 minutes, while the warm ischemia time was 47 ± 17.0 minutes, and the cold ischemia time was 245 ± 30.9 minutes. Early postoperative survival (up to 30 days) was 90%, with an overall incidence of clinically significant complications of 40–50%, most often of vascular, infectious, or hemorrhagic origin. |
