| Abstract [eng] |
Layered double hydroxides (LDHs) are a class of ionic layered compounds consisting of positively charged brucite-type layers, with charge-compensating anions and adsorbed water molecules in the interlayer region. These compounds are studied for their wide range of modification possibilities—ions can be replaced both in the cationic metal oxide layer and in the interlayer space, thereby obtaining the desired material properties. One of the many application areas for these materials is medicine. The need to use LDH for the treatment, diagnosis, and prevention of diseases stems from problems that are difficult for humanity to overcome, such as antibiotic resistance, the ineffectiveness of traditional disinfection methods against microorganisms, and ineffective disease treatment. Due to all these problems, there is a growing need for substances that are simple and quick to synthesize, widely applicable, and have a long-lasting (stable) effect. The aim of this work is to synthesize and investigate layered double hydroxides (LDHs) with properties relevant to antibacterial and drug delivery systems. During the study, Mg-Al LDHs were successfully synthesized.In these compounds some of the metals were replaced with Cr or Ag ions. The incorporation of Cr into the LDH structure was successful even at high concentrations, but these samples did not exhibit any antibacterial activity. The incorporation of Ag into the LDH structure was limited—most of the silver deposited on the LDH surface—but it still exhibited excellent antibacterial properties. By modifying the LDH interlayer, sodium benzenesulfonate (SBS) was successfully incorporated in molecules and influence of SBS content and different synthesis routes on the final properties of the LDH-SBS product was investigated. The most successful method of molecular insertion was interlayer reconstruction from nitrate LDH. The insertion of silver sulfadiazine (AgSD) into the LDH structure was complicated—due to the material’s limited solubility and structural complexity, insertion into the LDH interlayers was only partially successful. |
