| Title |
Development of electrochemical sensors for ibuprofen detection |
| Authors |
Hassan, Islam Moustafa Mohammed Mohammed |
| Full Text |
|
| Pages |
43 |
| Keywords [eng] |
Ibuprofen, electrochemical sensor, glassy carbon electrode, graphene–chitosan, cyclic voltammetry, differential pulse voltammetry, standard addition method, environmental monitoring, pharmaceutical contaminants, electrochemical oxidation |
| Abstract [eng] |
This study investigates the development of a simple and cost‑effective electrochemical platform for IBF detection using modified electrode systems. GPF/ITO electrodes were initially examined but showed insufficient electrochemical performance, leading to the evaluation of activated GCE and Gr-Chit/GCE as alternative sensing interfaces. Electrochemical characterization confirmed that Gr-Chit/GCE provided a substantially higher ECSA and improved analytical response toward IBF. Using CV, a linear range of 100-676 µM was obtained with a normalized sensitivity of 0.239 µA µM⁻¹ cm⁻².(R² = 0.998). DPV further enhanced analytical performance, yielding an LOD of 18.5 µM and an LOQ of 61.6 µM and a normalized sensitivity of 0.394 µA µM⁻¹ cm⁻². The sensor demonstrated good selectivity, with AA and ACT producing negligible interference. Its applicability was validated in tap water using the standard addition method, where the estimated concentration closely matched the nominal value, confirming good analytical accuracy. Overall, the Gr-Chit/GCE platform offers a practical and reliable approach for IBF detection in environmental samples. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2026 |
