| Authors |
Marques, Diogo F P ; Rose, Angela M C ; Monge, Susana ; Martínez-Baz, Iván ; Reynders, Marijke ; Duffy, Róisín ; Marbus, Sierk D ; Bino, Silvia ; Husa, Petr ; Dürrwald, Ralf ; Luong Nguyen, Liem Binh ; Petrović, Goranka ; Oroszi, Beatrix ; Bella, Antonino ; Kuliešė, Monika ; Abela, Stephen ; Paradowska-Stankiewicz, Iwona ; Machado, Ausenda ; Popovici, Odette ; Robertson, Chris ; Pozo, Francisco ; Lameiras Azevedo, Ana S ; Trobajo-Sanmartín, Camino ; Parys, Anna ; Domegan, Lisa ; van Gageldonk-Lafeber, Arianne B ; Součková, Lenka ; Tolksdorf, Kristin ; Launay, Odile ; Višekruna Vučina, Vesna ; Túri, Gergő ; Riccardo, Flavia ; Jančorienė, Ligita ; Cauchi, John Paul ; Gómez, Verónica ; Lazar, Mihaela ; McMenamin, Jim ; Nunes, Baltazar |
| Abstract [eng] |
INTRODUCTION: Older adults face an increased risk of influenza-related intensive care unit (ICU) admission and in-hospital death (IHD). Although vaccination reduces hospitalization, its effect on these outcomes remains uncertain. We estimated the association between influenza vaccination and both outcomes among adults aged ≥65 years hospitalized with laboratory-confirmed influenza.
RESEARCH DESIGN AND METHODS: We conducted a retrospective cohort study using European I-MOVE hospital network data (2015/16-2024/25); vaccination was defined as vaccine receipt ≥14 days before symptom onset. We estimated pooled-season adjusted risk ratios (aRR) using Poisson regression adjusting for potential confounders. We calculated relative risk reduction (RRR) as (1-aRR)×100, overall and by age group (65-79, ≥80 years).
RESULTS: After exclusions, 4,257 patients (five study sites, six seasons) were included. ICU admission occurred in 3% of vaccinated and 5% of unvaccinated patients; IHD occurred in 5% of both groups. RRR was 11% (95% CI: -21-34) against ICU admission (65-79 years: -4%; ≥80 years: 44%). RRR against IHD was 26% (95% CI: 3-43); 17% and 29% in each respective age group.
CONCLUSIONS: Vaccination showed little or no association with ICU admission, but was associated with a one-quarter reduction in IHD among hospitalized older adults, reinforcing its benefits against fatal in-hospital outcomes. |
