| Title |
A photoredox C–H arene functionalization toward substituted methyls |
| Authors |
Žurauskas, Jonas ; Radzevičius, Nojus ; Vaickūnas, Paulius ; Sergejevaitė, Gabija ; Orentas, Edvinas |
| DOI |
10.1021/jacs.6c04756 |
| Full Text |
|
| Is Part of |
Journal of the American Chemical Society.. Washington : American Chemical Society. 2026, vol. 148, iss. 28, p. 29876-29882.. ISSN 0002-7863. eISSN 1520-5126 |
| Abstract [eng] |
The ability to introduce modular C1 units directly into arene C–H bonds remains a fundamental challenge in synthetic design, limiting access to highly diversified molecular architectures from simple feedstocks. We disclose a photoredox-neutral platform that enables direct transfer of a methylene pyridinium linchpin to unactivated arenes, transforming inert C–H sites into versatile synthetic handles. The resulting benzylpyridinium products function as broadly addressable intermediates, supporting a wide range of C–C and C–heteroatom bond formation and granting streamlined access to medicinally privileged substituted methyls. |
| Published |
Washington : American Chemical Society |
| Type |
Journal article |
| Language |
English |
| Publication date |
2026 |
| CC license |
|
