| Title |
Synthesis of 4,6-disubstituted thieno[2,3-d]pyrimidines from 4,6-dichloro-2-methylthiopyrimidine-5-carbaldehyde / |
| Authors |
Tumkevičius, Sigitas ; Kaminskas, Andrius ; Bučinskaitė, Virginija ; Labanauskas, Linas |
| DOI |
10.1515/HC.2003.9.1.89 |
| Full Text |
|
| Is Part of |
Heterocyclic communications.. Berlin. 2003, vol. 9, no. 1, p. 89-94.. ISSN 0793-0283. eISSN 2191-0197 |
| Abstract [eng] |
Treatment of 4,6-dichloro-2-methylthiopyrimidine-5-carbaldehyde (1) with (1H-benzimidazol-2-yl)methanethiol afforded 6-(1H-benzimidazol-2-yl)-4-chloro-2-methylthiothieno[2,3-d]pyrimidine (g). Reaction of 1 with ethyl mercaptoacetate depending on its amount gave ethyl (4-chloro-2-methylthio-5-formylpyrimidin-6- ylthio)acetate (4) or 4,6-bis(ethoxycarbonylmethylthio)pyrimidine-5-carbaldehyde (g). Heating 4, in dimethyl sulfoxide or ethanol in the presence of base afforded ethyl 4-oxo-3,4-dihydro- (6) and 4-ethoxycarbonylmethylthiothieno[2,3-d]pyrimidine-6-carboxylates(7), respectively... |
| Published |
Berlin |
| Type |
Journal article |
| Language |
English |
| Publication date |
2003 |
| CC license |
|
