| Title |
Lietuvos populiacijos genetinės struktūros ir evoliucinių veiksnių analizė, remiantis plataus masto genotipavimo duomenimis: praeitis ir dabartis / |
| Translation of Title |
Evaluation of genetic structure and evolutionary forces of the Lithuanian population according to the high-density genotyping data: past and the future. |
| Authors |
Urnikytė, Alina |
| Full Text |
|
| Pages |
148 |
| Keywords [eng] |
Population genetic structure ; natural selection ; effective population size ; Lithuanian population |
| Abstract [eng] |
The contemporary Lithuanian population is composed of a complex mixture of the former Baltic tribes. Thus, the roots of the present day Lithuanian population are deep, with a high probability that the inhabitants of present-day Lithuania have preserved the ancient genetic composition. The availability of high-throughput genotyping platforms and next generation sequencing techniques and the development of new statistical and computational methods in the field of evolutionary genomics allow to infer evolutionary forces and finer scale population genetic structure. The analysis of geographically specific regions and the characterization of fine-scale patterns of genetic diversity may facilitate a much better understanding of the microevolutionary processes affecting local human populations. In this study we aimed to analyse local patterns of Lithuanian population genetic structure in comparison with other populations and evolutionary forces: effective population size, divergence time and signatures of adaptive positive selection from genome-wide high–density SNP genotyping data. Furthermore, past events between the two main ethnolinguistic groups (Aukstaiciai and Zemaiciai) of Lithuania using effective population size and estimated divergence time were reconstructed. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Doctoral thesis |
| Language |
Lithuanian |
| Publication date |
2018 |
