| Title |
Nutritional anemia relation to changes of health indicators and fecal microbiota in infancy and early childhood / |
| Translation of Title |
Kūdikių ir mažų vaikų mitybinių mažakraujysčių ryšys su sveikatos rodiklių ir išmatų mikrobiotos pokyčiais. |
| Authors |
Mulevičienė, Audronė |
| Full Text |
|
| Pages |
56 |
| Keywords [eng] |
infants ; children ; anemia ; gut microbiota |
| Abstract [eng] |
Nutritional anemia in infants and young children is a relevant problem in Lithuania. Nevertheless, previously the highest attention was paid to early diagnosis and treatment of anemia. The aim of this study was to evaluate the relationship between nutritional anemia and changes of health indicators and fecal microbiota in infants and young children up to 36 months of age in Vilnius district. It was found that low birthweight and early doubling of the birthweight was associated with nutritional iron deficiency anemia (nIDA). Low diet diversity increased the risk of developing nIDA in infancy and a later introduction of meat, consumption of unmodified cow’s milk and products with added sugar increased the risk of developing nIDA in second and third years of life. The greatest problems of nutritional anemia prophylaxis in primary healthcare were found to be a lack of breastfeeding promotion, protection and support; inappropriate complementary feeding recommendations and gaps in the use of specific prophylactic measures. Next-generation sequencing of the V3-V4 hypervariable region of the 16S rRNA gene revealed that nIDA was associated with unfavorable gut microbiota changes: a decreased Bifidobacteriaceae/ Enterobacteriaceae ratio and relative abundance of Coriobacteriaceae, increased Veillonellaceae relative abundance. As a result, a prophylaxis algorithm for nIDA was developed. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Summaries of doctoral thesis |
| Language |
English |
| Publication date |
2018 |
