| Title |
SKEMPI 2.0: an updated benchmark of changes in protein–protein binding energy, kinetics and thermodynamics upon mutation / |
| Authors |
Jankauskaitė, Justina ; Jiménez-García, Brian ; Dapkūnas, Justas ; Fernandez-Recio, Juan ; Moal, Iain H |
| DOI |
10.1093/bioinformatics/bty635 |
| Full Text |
|
| Is Part of |
Bioinformatics.. London : Oxford University Press. 2019, vol. 35, iss. 3, p. 462-469.. ISSN 1367-4803. eISSN 1460-2059 |
| Keywords [eng] |
protein-protein ; binding energy ; kinetics ; thermodynamics |
| Abstract [eng] |
Motivation: Understanding the relationship between the sequence, structure, binding energy, binding kinetics and binding thermodynamics of protein–protein interactions is crucial to understanding cellular signaling, the assembly and regulation of molecular complexes, the mechanisms through which mutations lead to disease, and protein engineering. |
| Published |
London : Oxford University Press |
| Type |
Journal article |
| Language |
English |
| Publication date |
2019 |
