Title Arterial destiffening starts early after renal artery denervation /
Authors Berūkštis, Andrius ; Navickas, Rokas ; Neverauskaitė-Piliponienė, Gintarė ; Ryliškytė, Ligita ; Misiūra, Jonas ; Vajauskas, Donatas ; Misonis, Nerijus ; Laucevičius, Aleksandras
DOI 10.1155/2019/3845690
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Is Part of International journal of hypertension.. London : Hindawi Ltd. 2019, vol. 2019, art. no. 3845690, p. [1-7].. ISSN 2090-0384. eISSN 2090-0392
Keywords [eng] Hypertension ; renal denervation ; arterial stiffening
Abstract [eng] Introduction. Renal artery denervation (RDN) is a new widely discussed method in treatment of hypertension. Most of the RDN studies assessed BP and arterial changes 3 and 6 months after the procedure, but there is a lack of trials that investigated early changes after RDN. Aim. To investigate aortic stiffness 24-48 hours after the procedure and thus to examine whether RDN might have an early additive value for a cardiovascular risk decline beyond the lowering of blood pressure. Methods. RDNwas performed for 73 patients with resistant hypertension. Arterial stiffness and central haemodynamics were measured before the procedure, the next day after the procedure, and subsequently after 1, 3, 6, and 12 months. Results. Within 48 hours, RDN significantly reduced aortic pulse wave velocity (AoPWV) from11.3±2.7 to 10.3±2.6 m/s (p=0.001); reductionwas sustained atmonths 1, 3, 6, and 12. Early changes in the AoPWV value did not correlate with changes in office systolic or diastolic BP (p=0.45; p=0.33). Furthermore, the higher the initial AoPWV value, the greater the reduction of AoPWV observed after 6 months: Q1 8.4±1, Δ0.05±1.6 / Q2 10.1±0.4, Δ1.1±1.4 / Q3 12.2±0.8, Δ1.8±1.7 / Q4 15.3±1.7, Δ2.8±2.1 (p=0.002). Conclusions. Early and sustained effects on AoPWV observed in our study suggest that RDN may have additional effects on reducing arterial stiffness and cardiovascular risk.
Published London : Hindawi Ltd
Type Journal article
Language English
Publication date 2019