| Title |
Functional data analysis of regional brain neurophysiological activity influenced by chronic ethanol consumption / |
| Translation of Title |
Smegenų centrų paveiktų chroniško etanolio vartojimo, neurofiziologinės veiklos tyrimas taikant funkcinės duomenų analizės metodus. |
| Authors |
Danielius, Tadas |
| Full Text |
|
| Pages |
35 |
| Keywords [eng] |
Functional Data Analysis, Functional Principal Component Analysis, VARIMAX, Continuous Wavelet transform, Nucleus Accumbens, rat brains, lamotrigine, Funkcinė duomenų analizė, funkcinės principinės komponentės, tolydi vilnelės transformacija, žiurkių smegenys |
| Abstract [eng] |
Lamotrigine with anti-glutamatergic properties may have potential utility as novel treatments for alcoholism. Nevertheless, to which extent different neurotransmitter systems contribute to the development of behavioral inflexibility in alcoholism is not entirely clear. In order to understand it better understand it, behavioural animal model of long-term voluntary alcohol taking behaviour experiment was done. In this study functional data analysis of recorded neurophysiological data revealed that the third functional principal component (PC) had significant changes during drinking bout, while animal was injected with lamotrigine. Analysis of PCs showed that background brain process accounted for roughly 60% of variability. After applying VARIMAX rotation, PCs highlighted time segments, which may help to understand brain dynamics leading to decision making process in brains. Continuous wavelet transform analysis of the third PC display 4 times stronger power spectrum levels when animal was injected with drug. |
| Dissertation Institution |
Vilniaus universitetas. |
| Type |
Master thesis |
| Language |
English |
| Publication date |
2018 |
