| Title |
Virškinimo trakto stromos navikų chirurginio gydymo principai / |
| Translation of Title |
Principles of surgical treatment of gastrointestinal stromal tumors. |
| Authors |
Lunevičius, Raimundas ; Fujiwara, Michitaka ; Stanaitis, Juozas |
| DOI |
10.15388/LietChirur.2006.2.2270 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija.. Vilnius : Vilniaus universiteto leidykla. 2006, t. 4, Nr. 2, p. 104-109.. ISSN 1392-0995. eISSN 1648-9942 |
| Keywords [eng] |
gastrointestinal stromal tumors (GIST) ; surgery ; imatinib mesylate |
| Abstract [eng] |
Background/objective. Surgical resection is the main choice of reliable recovery for GIST patients. The purpose of the article is as follows: to define indications for surgery, the principles of operations due to GIST, and late follow-up results. Review. Most important points in defining indications for surgery are the following: (i) is it a primary localized resectable GIST? If yes, it is an absolute indication for surgery; (ii) is it a locally or distantly outspread GIST when the possibilities of surgical resection are very restricted or there are no them; if yes, it is an indication for neoadjuvant imatinib mesylate therapy. There is a need for re-consideration of indications for surgery after 3, 6, 9 and more months after permanent neoadjuvant therapy, depending on response of the tumor to medication. An operation should be aimed to performe complete en block removal of the tumor and the surrounding 1–2 cm length of tissue. A systematic regional lymphadenectomy is not recommended routinely. It is warranted only for evident regional nodal involvement. In case of a recurrent or metastatic disease, there is a necessity to determine the following: first, are threre still any possibilities for surgical resection; second, to motivate the necessity for imatinib mesylate therapy. Binary categorization of GIST into low and high malignant potential tumors is acceptable to clinicians. Conclusion. To optimize results of GIST management, a further active research and consensus are needed. |
| Published |
Vilnius : Vilniaus universiteto leidykla |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2006 |
| CC license |
|
