| Title |
Imuninė sensitizacija po dirbtinės širdies prijungimo / |
| Translation of Title |
Immune sensitization after artificial heart support device implantation. |
| Authors |
Malickaitė, Radvilė ; Stanevičienė, Aldona-Marija ; Ručinskas, Kęstutis ; Jurgauskienė, Laimutė-Genovaitė ; Miniauskas, Saulius ; Sirvydis, Vytautas-Jonas |
| DOI |
10.15388/LietChirur.2007.3.2208 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija. 2007, t. 5, Nr. 3, p. 366-370.. ISSN 1392-0995 |
| Abstract [eng] |
Objective: This study was designed to characterize alterations in the immune system of patients who received artificial heart (AH) placement therapy for end-stage heart failure as a bridge to heart transplantation at the Vilnius University Cardial Surgery Centre. Patients and methods: Immunological studies were performed in 8 pts awaiting cardiac transplantation with AH assist (7 of them were transplanted after 75-1050 days of support). Immunological indices before AH placement and after one month of mechanical assistance (period free from infection) were compared. Fluorochrome-labeled Mabs were used for immunophenotypic analysis of circulating T cells and apoptocic activity evaluation. Antibodies against HLA class I molecules were detected by a standard microlymphocytotoxic test. Results: AH recipients showed relative lymphopenia, reduction in CD4 T cell counts, a decreased CD+4+ / CD8+ ratio. Six of the eight recipients with long-term support did not produce HLA antibodies despite receiving blood products during support. Conclusion: In conclusion, these results suggest that reduction in CD4+ T cell levels accompanying AH support may increase the prevalence of infectious complications and HLA sensitization. |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2007 |
| CC license |
|
