| Title |
Ūminio kepenų transplantato atmetimo diferencinė diagnostika iš bioptato / |
| Translation of Title |
The differential diagnosis of acute liver allograft rejection in the biopsy. |
| Authors |
Barakauskienė, Aušrinė ; Laurinavičius, Arvydas ; Strupas, Kęstutis ; Buivydienė, Arida ; Sokolovas, Vitalijus ; Paškonis, Marius ; Valantinas, Jonas ; Jurgaitis, Jonas |
| DOI |
10.15388/LietChirur.2007.4.2171 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija. 2007, t. 5(4), p. 495-506.. ISSN 1392-0995 |
| Keywords [eng] |
Liver allograft rejection ; Acute (cellular) rejection ; Banff scheme ; “Time-zero‿ biopsy ; Rejection activity index |
| Abstract [eng] |
Background / objective Histological assessment of liver biopsies provides important information for the management of patients undergoing liver transplantation and for the differential diagnosis of other diseases. The aim of the article is to summarize the theoretical knowledge obtained from the University of Heidelberg at the Institute of Pathology participating in the Leonardo da Vinci project “Competence improvement in liver transplantation” in April–Juny 2006, and our own experience to determine acute (cellular) rejection, “time-zero” biopsy. Results There are three main morphological criteria of the rejection activity index to be evaluated: portal tract inflammation, bile duct damage and venous endothelial inflammation. The main histological features of acute (cellular) rejection are described and assessed in six pictures, and a practical approach to the scoring system (Banff scheme) is presented. In addition, there are described morphological changes caused by drugs as a response to treatment. Conclusions The assessment of acute (cellular) rejection should be carried out together with clinicians, surgeons, immunologists and pathologists working in team. The capability to evaluate all the clinical and morphological data in complex ensures the quality of life of the patient after liver transplantation. |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2007 |
| CC license |
|
