Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia? /

Sandra Kutkienė; Žaneta Petrulionienė; Aleksandras Laucevičius; Rimantė Čerkauskienė; Vytautas Kasiulevičius; Artūras Samuilis; Virginija Augaitienė; Akvilė Gedminaitė; Gintarė Bieliauskienė; Akvilė Šaulytė-Mikulskienė; Justina Staigytė; Emilija Petrulionytė; Urtė Gargalskaitė; Eglė Skiauterytė; Gabija Matuzevičienė; Milda Kovaitė; Irena Nedzelskienė

doi:10.1186/s12944-019-1090-8

Title	Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia? /
Authors	Kutkienė, Sandra ; Petrulionienė, Žaneta ; Laucevičius, Aleksandras ; Čerkauskienė, Rimantė ; Kasiulevičius, Vytautas ; Samuilis, Artūras ; Augaitienė, Virginija ; Gedminaitė, Akvilė ; Bieliauskienė, Gintarė ; Šaulytė-Mikulskienė, Akvilė ; Staigytė, Justina ; Petrulionytė, Emilija ; Gargalskaitė, Urtė ; Skiauterytė, Eglė ; Matuzevičienė, Gabija ; Kovaitė, Milda ; Nedzelskienė, Irena
DOI	10.1186/s12944-019-1090-8
Full Text
Is Part of	Lipids in health and disease.. London : BioMed Central. 2019, vol. 18, art. no. 149, p. [1-9].. ISSN 1476-511X. eISSN 1476-511X
Keywords [eng]	Coronary artery calcium score ; Cardiovascular risk ; Severe hypercholesterolemia ; Dyslipidemia ; Primary prevention
Abstract [eng]	Background: Coronary artery calcium (CAC) is known as a reliable tool for estimating risk of myocardial infarction, coronary death, all-cause mortality and is even used to evaluate suitable asymptomatic patients. We therefore aimed to evaluate whether CAC scoring can be applied in the algorithm for clinical examination of patients with severe hypercholesterolemia (SH). Methods: During the period of 2016–2017 a total of 213 asymptomatic adults, underwent computed tomography angiography to evaluate their CAC scoring. The sample consisted of 110 patients with SH and 103 age and sex matched controls without dyslipidemia and established cardiovascular disease. Results: In total there were 79 (37.2%) subjects with elevated (≥25th) CAC percentiles. Out of them 47 (59.5%) had SH and 32 (40.5%) did not. CAC score did not differ between groups (SH (+) 140.30 ± 185.72 vs SH (−) 87.84 ± 140.65, p = 0.146), however there was a comparable difference in how the participants of these groups distributed among different percentile groups (p = 0.044). Gender, blood pressure, tabaco use, physical activity, family history of coronary artery disease and diabetes mellitus were not associated with CAC score (p > 0.05). There were no significant correlations between biochemical parameters and CAC percentiles except for increase in lipoprotein(a) (p = 0.038). Achilles tendon pathology, visceral obesity, body mass index and increased waist-hip ratio were not associated with CAC percentiles either (p > 0.05). Conclusions: CAC score is not associated with presence of SH. CAC score is not an appropriate diagnostic tool in the algorithm for clinical examination of patients with SH. Further larger studies are needed to support our findings.
Published	London : BioMed Central
Type	Journal article
Language	English
Publication date	2019

„Is the coronary artery calcium score the first-line tool for investigating patients with severe hypercholesterolemia? /“