| Title |
Vaikų tarpuplaučio pirminiai germinogeniniai navikai / |
| Translation of Title |
Primary germinative cell tumors in children. |
| Authors |
Maknavičius, Stanislovas ; Valiulis, Arūnas ; Prapuolenienė, Žydrūnė |
| DOI |
10.15388/LietChirur.2008.4.2143 |
| Full Text |
|
| Is Part of |
Lietuvos chirurgija.. Vilnius : Vilniaus universiteto leidykla. 2008, t. 6, Nr. 4, p. 271-275.. ISSN 1392-0995. eISSN 1648-9942 |
| Keywords [eng] |
mediastinal tumours in children ; mediastinal germ cell tumour in children ; benign and malignant mediastinal teratoma |
| Abstract [eng] |
Background/objective. Primary germ cell tumour is the most common mediastinal tumour in children. It may be benign or malignant, or cystic and contain three types of embryonal developing tissue – ectoderm, mesoderm and endoderm. Germ cell tumour can be seminomatous, nonseminomatous and originate from ectopic tissues in the mediastinum. Malignant tumours lesions grow and invade the surrounding structures. Germ cell tumour of the mediastinum in children may present with early puberty in Klinefelter’s syndrome. Children with malignant germ cell tumours often have elevated alpha-fetoprotein and serum beta-chorionic gonadotropin levels. The aim of this study was to review the spectrum of clinical symptoms, diagnostics methods and tactics of the surgical treatment. Patients and methods. We analysed retrospectively 8 children’s case histories with primary germ cell tumours in the period 1995–2007. Clinical symptoms, diagnostic methods, methods of surgical treatment and histological diagnoses were analysed. Results. Three patients had malignant and five patients had benign tumours. Respiratory distress syndrome was present in all patients. Qur data are based on histological analysis after operations. Seven patients were operated on. The tumours were removed. Conclusions. Mediastinal germ cell tumours in children are embryonal multipotentional histological structures of embryonic origin, developing of endodermal, mesodermal and ectodermal tissues. The most frequent symptoms were respiratory distress, chest pain, temperature, cough and wheezing. Patients with teratomas of germ cell tumours often have an elevated level of alpha-fetoprotein and serum beta-human gonadotropin. Seven patients were operated on, tumours were removed, and diagnoses were based on histological analysis. |
| Published |
Vilnius : Vilniaus universiteto leidykla |
| Type |
Journal article |
| Language |
Lithuanian |
| Publication date |
2008 |
| CC license |
|
